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Nutritional Modulation of Sleep Latency, Duration, and Efficiency: A Randomised, Repeated-Measures, Double-Blind Deception Study.

Langan-Evans, C, Hearris, MA, Gallagher, C, Long, S, Thomas, C, Moss, AD, Cheung, W, Howatson, G and Morton, JP (2022) Nutritional Modulation of Sleep Latency, Duration, and Efficiency: A Randomised, Repeated-Measures, Double-Blind Deception Study. Medicine and Science in Sports and Exercise, 55 (2). pp. 289-300. ISSN 0195-9131

Langan-Evans et al. 2022 Nutritional Modulation of Sleep Latency Duration and Efficiency_A Randomised Repeated-Measures Double Blind Deception Study_Accepted Version.pdf - Accepted Version
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Purpose: To test the hypothesis that a novel nutritional blend comprised of tryptophan, glycine, magnesium, tart cherry powder and L-theanine, enhances subjective and objective measures of sleep during free living conditions.
Methods: In a randomised, repeated measures crossover and double blind deception design, participants (n = 9 male and 7 female; age: 24 ± 3 years; body mass: 69.8 ± 11.6 kg; stature: 170.8 ± 9.1 cm) completed a 3 day familiarisation period, followed by 3 day intervention and placebo trials. Subjective Pittsburgh Quality Sleep Index, Core Consensus Sleep Diary and Karolinska Sleepiness Scale survey tools, alongside objective actigraphy measures of sleep were assessed, with daily nutritional intake, activity and light exposure standardised between trials. Participants provided daily urine samples for assessment of targeted and untargeted metabolomes.
Results: The intervention trial reduced sleep onset latency (-24 ± 25 mins; p = 0.002), increased total sleep time (22 ± 32 mins; p = 0.01) and sleep efficiency (2.4 ± 3.9 %; p = 0.03), whilst also reducing morning sleepiness (p = 0.02). Throughout the study, 75 % of participants remained blinded to sleep assessment as a primary outcome measure, with 56 % subjectively indicating improved sleep during the intervention trial. Metabolomic analysis highlighted several significantly altered metabolomes related to sleep regulation between trials, inclusive of 6-sulfatoxymelatonin, D-serine and L-glutamic acid.
Conclusions: Data demonstrate that employing the proposed blend of novel nutritional ingredients during free living conditions reduced sleep onset latency, increased total sleep duration and increased sleep efficiency, leading to reduced perceptions of morning sleepiness. These effects may be mediated by the upregulation of key metabolites involved in the neurophysiological modulation of the sleep/wake cycle.

Item Type: Article
Additional Information: This is the Author Accepted Manuscript version. The version of record can be found here http://doi.org/10.1249/mss.0000000000003040
Uncontrolled Keywords: Male; Female; Humans; Young Adult; Adult; Sleep Latency; Sleepiness; Sleep; Actigraphy; Double-Blind Method; Deception; 1106 Human Movement and Sports Sciences; 1116 Medical Physiology; 1117 Public Health and Health Services; Sport Sciences
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
G Geography. Anthropology. Recreation > GV Recreation Leisure > GV561 Sports
Divisions: Sport & Exercise Sciences
Publisher: Lippincott, Williams & Wilkins
SWORD Depositor: A Symplectic
Date Deposited: 07 Feb 2023 14:09
Last Modified: 12 Sep 2023 00:50
DOI or ID number: 10.1249/mss.0000000000003040
URI: https://researchonline.ljmu.ac.uk/id/eprint/18756
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