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The developmental impacts of natural selection on human pelvic morphology

Young, M, Richard, D, Grabowski, M, Auerbach, BM, De Bakker, BS, Hagoort, J, Muthuirulan, P, Kharkar, V, Kurki, HK, Betti, L, Birkenstock, L, Lewton, KL and Capellini, TD (2022) The developmental impacts of natural selection on human pelvic morphology. Science Advances, 8 (33). ISSN 2375-2548

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Open Access URL: https://doi.org/10.1126/sciadv.abq4884 (Published version)


Evolutionary responses to selection for bipedalism and childbirth have shaped the human pelvis, a structure that differs substantially from that in apes. Morphology related to these factors is present by birth, yet the developmental-genetic mechanisms governing pelvic shape remain largely unknown. Here, we pinpoint and characterize a key gestational window when human-specific pelvic morphology becomes recognizable, as the ilium and the entire pelvis acquire traits essential for human walking and birth. We next use functional genomics to molecularly characterize chondrocytes from different pelvic subelements during this window to reveal their developmental-genetic architectures. We then find notable evidence of ancient selection and genetic constraint on regulatory sequences involved in ilium expansion and growth, findings complemented by our phenotypic analyses showing that variation in iliac traits is reduced in humans compared to African apes. Our datasets provide important resources for musculoskeletal biology and begin to elucidate developmental mechanisms that shape human-specific morphology.

Item Type: Article
Uncontrolled Keywords: Pelvis; Animals; Hominidae; Humans; Pregnancy; Parturition; Female; Selection, Genetic; Biological Evolution; Animals; Biological Evolution; Female; Hominidae; Humans; Parturition; Pelvis; Pregnancy; Selection, Genetic
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QM Human anatomy
Divisions: Biological & Environmental Sciences (from Sep 19)
Publisher: American Association for the Advancement of Science
SWORD Depositor: A Symplectic
Date Deposited: 08 Feb 2023 12:06
Last Modified: 08 Feb 2023 12:15
DOI or ID number: 10.1126/sciadv.abq4884
URI: https://researchonline.ljmu.ac.uk/id/eprint/18826
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