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Long-term cardiovascular health status and physical functioning of nonhospitalized patients with COVID-19 compared with non-COVID-19 controls

van der Sluijs, KM, Bakker, EA, Schuijt, TJ, Joseph, J, Kavousi, M, Geersing, GJ, Rutten, FH, Hartman, YAW, Thijssen, DHJ and Eijsvogels, TMH (2022) Long-term cardiovascular health status and physical functioning of nonhospitalized patients with COVID-19 compared with non-COVID-19 controls. AJP - Heart and Circulatory Physiology, 324 (1). H47-H56. ISSN 0363-6135

Long-term cardiovascular health status and physical functioning of non-hospitalized COVID-19 patients compared to non-COVID-19 controls .pdf - Accepted Version

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Coronavirus disease 2019 (COVID-19) is reported to have long-term effects on cardiovascular health and physical functioning, even in the nonhospitalized population. The physiological mechanisms underlying these long-term consequences are however less well described. We compared cardiovascular risk factors, arterial stiffness, and physical functioning in nonhospitalized patients with COVID-19, at a median of 6 mo postinfection, versus age- and sex-matched controls. Cardiovascular risk was assessed using blood pressure and biomarker concentrations (amino-terminal pro-B-type-natriuretic-peptide, high-sensitive cardiac troponin I, C-reactive protein), and arterial stiffness was assessed using carotid-femoral pulse wave velocity. Physical functioning was evaluated using accelerometry, handgrip strength, gait speed and questionnaires on fatigue, perceived general health status, and health-related quality of life (hrQoL). We included 101 former patients with COVID-19 (aged 59 [interquartile range, 55-65] yr, 58% male) and 101 controls. At 175 [126-235] days postinfection, 32% of the COVID-19 group reported residual symptoms, notably fatigue, and 7% required post-COVID-19 care. We found no differences in blood pressure, biomarker concentrations, or arterial stiffness between both groups. Former patients with COVID-19 showed a higher handgrip strength (43 [33- 52] vs. 38 [30-48] kg, P = 0.004) and less sleeping time (8.8 [7.7-9.4] vs. 9.8 [8.9-10.3] h/day, P < 0.001) and reported fatigue more often than controls. Accelerometry-based habitual physical activity levels, gait speed, perception of general health status, and hrQoL were not different between groups. In conclusion, one in three nonhospitalized patients with COVID-19 reports residual symptoms at a median of 6 mo postinfection, but we were unable to relate these symptoms to increases in cardiovascular risk factors, arterial stiffness, or physical dysfunction.

Item Type: Article
Uncontrolled Keywords: Humans; Fatigue; Hand Strength; Health Status; Quality of Life; Female; Male; Vascular Stiffness; Pulse Wave Analysis; Biomarkers; COVID-19; COVID-19; cardiovascular health; long-term effects; nonhospitalized; physical functioning; Humans; Male; Female; Pulse Wave Analysis; Quality of Life; Hand Strength; COVID-19; Vascular Stiffness; Health Status; Fatigue; Biomarkers; 0606 Physiology; 1116 Medical Physiology; Cardiovascular System & Hematology
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: American Physiological Society
SWORD Depositor: A Symplectic
Date Deposited: 10 Mar 2023 10:46
Last Modified: 16 Dec 2023 00:50
DOI or ID number: 10.1152/ajpheart.00335.2022
URI: https://researchonline.ljmu.ac.uk/id/eprint/19066
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