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The influence of environmental and core temperature on cyclooxygenase and PGE2 in healthy humans

Esh, CJ, Chrismas, BCR, Mauger, AR, Cherif, A, Molphy, J and Taylor, L (2021) The influence of environmental and core temperature on cyclooxygenase and PGE2 in healthy humans. Scientific Reports, 11 (1). ISSN 2045-2322

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Open Access URL: https://doi.org/10.1038/s41598-021-84563-5 (Published version)


Whether cyclooxygenase (COX)/prostaglandin E2 (PGE2) thermoregulatory pathways, observed in rodents, present in humans? Participants (n = 9) were exposed to three environments; cold (20 °C), thermoneutral (30 °C) and hot (40 °C) for 120 min. Core (Tc)/skin temperature and thermal perception were recorded every 15 min, with COX/PGE2 concentrations determined at baseline, 60 and 120 min. Linear mixed models identified differences between and within subjects/conditions. Random coefficient models determined relationships between Tc and COX/PGE2. Tc [mean (range)] increased in hot [+ 0.8 (0.4–1.2) °C; p < 0.0001; effect size (ES): 2.9], decreased in cold [− 0.5 (− 0.8 to − 0.2) °C; p < 0.0001; ES 2.6] and was unchanged in thermoneutral [+ 0.1 (− 0.2 to 0.4) °C; p = 0.3502]. A relationship between COX2/PGE2 in cold (p = 0.0012) and cold/thermoneutral [collapsed, condition and time (p = 0.0243)] was seen, with higher PGE2 associated with higher Tc. A within condition relationship between Tc/PGE2 was observed in thermoneutral (p = 0.0202) and cold/thermoneutral [collapsed, condition and time (p = 0.0079)] but not cold (p = 0.0631). The data suggests a thermogenic response of the COX/PGE2 pathway insufficient to defend Tc in cold. Further human in vivo research which manipulates COX/PGE2 bioavailability and participant acclimation/acclimatization are warranted to elucidate the influence of COX/PGE2 on Tc.

Item Type: Article
Uncontrolled Keywords: Science & Technology; Multidisciplinary Sciences; Science & Technology - Other Topics; Humans; Dinoprostone; Body Temperature; Biological Availability; Body Temperature Regulation; Skin Temperature; Adult; Male; Cyclooxygenase 2; Cold Temperature; Hot Temperature; Adult; Biological Availability; Body Temperature; Body Temperature Regulation; Cold Temperature; Cyclooxygenase 2; Dinoprostone; Hot Temperature; Humans; Male; Skin Temperature
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Nature Publishing Group
SWORD Depositor: A Symplectic
Date Deposited: 10 Mar 2023 11:20
Last Modified: 10 Mar 2023 11:30
DOI or ID number: 10.1038/s41598-021-84563-5
URI: https://researchonline.ljmu.ac.uk/id/eprint/19072
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