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Evaluation of near-infrared chemical imaging for authenticating of antibiotics

Assi, S, Rowlands, S, Liatsis, P, Al Hamid, M, Mustafina, J, Ghaly Yousif, M, Coombs, T and Al-Jumeily OBE, D (2023) Evaluation of near-infrared chemical imaging for authenticating of antibiotics. Currents in Pharmaceutical Research, 1 (1).

Evaluation of Near-Infrared Chemical Imaging (NIR-CI) for the Authentication of Antibiotics.pdf - Published Version
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Counterfeit medicines represent a public health threat that leads to treatment ineffectiveness at its least and lethal effects at its worst. Near-infrared chemical imaging (NIR-CI) offers an informative and in-depth tool for several applications in the pharmaceutical industry particularly in medicines’ authentication. The aim of this work is to authenticate antibiotic tablets using NIR-CI. Tablets were measured non-destructively using a near-infrared microscope as follows: within their blister packaging, without their blisters, sectioned and crushed. The results showed that there was no marked difference in measuring the tablet within or without its blister packaging. The mean spectra of tablets showed high correlation coefficient values against the active pharmaceutical ingredient in case of authentic tablets. On the other hand, counterfeit tablets showed key differences from authentic alternatives with low correlation coefficient values. More specifically, counterfeit tablets showed poor distribution of the active pharmaceutical ingredient and excipients. In summary, the results have demonstrated the potential of NIR-CI in authenticating counterfeit tablets non-destructively.

Item Type: Article
Uncontrolled Keywords: antibiotics; chemical imaging; counterfeit medicines; near-infrared; NIR-CI
Subjects: Q Science > QA Mathematics > QA75 Electronic computers. Computer science
Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
Divisions: Computer Science & Mathematics
Pharmacy & Biomolecular Sciences
Publisher: UMT
SWORD Depositor: A Symplectic
Date Deposited: 29 Jun 2023 14:19
Last Modified: 12 Dec 2023 14:45
URI: https://researchonline.ljmu.ac.uk/id/eprint/20145
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