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Physical activity and sedentary behavior show distinct associations with tissue-specific insulin sensitivity in adults with overweight

Wanders, L, Gijbels, A, Bakker, EA, Trouwborst, I, Jardon, KM, Manusama, KCM, Hul, GB, Feskens, EJM, Afman, LA, Blaak, EE, Hopman, MTE, Goossens, GH and Thijssen, DHJ (2023) Physical activity and sedentary behavior show distinct associations with tissue-specific insulin sensitivity in adults with overweight. Acta Physiologica, 237 (4). ISSN 1748-1708

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Aim: The aim of this study is to investigate associations between the physical activity (PA) spectrum (sedentary behavior to exercise) and tissue-specific insulin resistance (IR). Methods: We included 219 participants for analysis (median [IQR]: 61 [55; 67] years, BMI 29.6 [26.9; 32.0] kg/m2; 60% female) with predominant muscle or liver IR, as determined using a 7-point oral glucose tolerance test (OGTT). PA and sedentary behavior were measured objectively (ActivPAL) across 7 days. Context-specific PA was assessed with the Baecke questionnaire. Multiple linear regression models (adjustments include age, sex, BMI, site, season, retirement, and dietary intake) were used to determine associations between the PA spectrum and hepatic insulin resistance index (HIRI), muscle insulin sensitivity index (MISI) and whole-body IR (HOMA-IR, Matsuda index). Results: In fully adjusted models, objectively measured total PA (standardized regression coefficient β = 0.17, p = 0.020), light-intensity PA (β = 0.15, p = 0.045) and moderate-to-vigorous intensity PA (β = 0.13, p = 0.048) were independently associated with Matsuda index, but not HOMA-IR (p > 0.05). A higher questionnaire-derived sport index and leisure index were associated with significantly lower whole-body IR (Matsuda, HOMA-IR) in men but not in women. Results varied across tissues: more time spent sedentary (β = −0.24, p = 0.045) and a higher leisure index (β = 0.14, p = 0.034) were respectively negatively and positively associated with MISI, but not HIRI. A higher sport index was associated with lower HIRI (β = −0.30, p = 0.007, in men only). Conclusion: While we confirm a beneficial association between PA and whole-body IR, our findings indicate that associations between the PA spectrum and IR seem distinct depending on the primary site of insulin resistance (muscle or liver).

Item Type: Article
Uncontrolled Keywords: Muscles; Liver; Humans; Insulin Resistance; Glucose Tolerance Test; Exercise; Aged; Middle Aged; Female; Male; Sedentary Behavior; exercise; insulin resistance; sitting; tissue-specific; Exercise; Sedentary Behavior; Insulin Resistance; Humans; Male; Female; Middle Aged; Aged; Glucose Tolerance Test; Muscles; Liver; 1106 Human Movement and Sports Sciences; 1116 Medical Physiology; Physiology
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Wiley
SWORD Depositor: A Symplectic
Date Deposited: 21 Jul 2023 14:42
Last Modified: 21 Jul 2023 14:45
DOI or Identification number: 10.1111/apha.13945
URI: https://researchonline.ljmu.ac.uk/id/eprint/20475

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