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Are there interindividual responses of cardiovascular disease risk markers to acute exercise? A replicated crossover study

Shen, T, Thackray, AE, King, JA, Alotaibi, TF, Alanazi, TM, Willis, SA, Roberts, MJ, Lolli, L, Atkinson, G and Stensel, DJ Are there interindividual responses of cardiovascular disease risk markers to acute exercise? A replicated crossover study. Medicine and Science in Sports and Exercise. ISSN 0195-9131 (Accepted)

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Purpose: Using a replicated crossover design, we quantified the response heterogeneity of postprandial cardiovascular disease (CVD) risk marker responses to acute exercise. Methods: Twenty men (mean (SD) age, 26 (6) years; BMI, 23.9 (2.4) kg·m-2) completed four, 2-day conditions (two control, two exercise) in randomised orders. On days 1 and 2, participants rested and consumed two high-fat meals over 9-h. Participants ran for 60-mins (61 (7)% of peak oxygen uptake) on day 1 (6.5-7.5 h) of both exercise conditions. Time-averaged total-area-under-the-curve (TAUC) for triacylglycerol (TAG), glucose and insulin were calculated from 11 venous blood samples on day 2. Arterial stiffness and blood pressure responses were calculated from measurements at baseline on day 1 and at 2.5-h on day 2. Consistency of individual differences was explored by correlating the two replicates of control-adjusted exercise responses for each outcome. Within-participant covariate-adjusted linear mixed models quantified participant-by-condition interactions and individual-response SDs. Results: Acute exercise reduced mean TAUC-TAG (-0.27 mmol·L-1 h; Cohen’s d = 0.29, P = 0.017) and TAUC-insulin (-24.45 pmol·L-1 h; Cohen’s d = 0.35, P = 0.022) vs. control, but led to negligible changes in TAUC-glucose and the vascular outcomes (Cohen’s d ≤ 0.41, P ≥ 0.106). Small-to-moderate, but nonsignificant, correlations were observed between the two response replicates (r = -0.40 to 0.15, P ≥ 0.066). We did not detect any individual response heterogeneity. All participant-by-condition interactions were P ≥ 0.137, and all individual-response SDs were small with wide 95% confidence intervals overlapping zero. Conclusion: Large trial-to-trial within-subject variability inhibited detection of consistent inter-individual variability in postprandial metabolic and vascular responses to acute exercise.

Item Type: Article
Additional Information: This is a pre-copyedited, author-produced version of an article accepted for publication in Medicine and Science in Sports and Exercise
Uncontrolled Keywords: 1106 Human Movement and Sports Sciences; 1116 Medical Physiology; 1117 Public Health and Health Services; Sport Sciences
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Lippincott, Williams & Wilkins
SWORD Depositor: A Symplectic
Date Deposited: 14 Aug 2023 12:36
Last Modified: 14 Aug 2023 14:18
URI: https://researchonline.ljmu.ac.uk/id/eprint/20720

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