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Effects of Methanol Leaf Extract of Mucuna pruriens on Male Anaemic Wister Rats

Ayo, VI, Abah, MA, Ekele, J, Ajiduku, AL and Abdullahi, S (2023) Effects of Methanol Leaf Extract of Mucuna pruriens on Male Anaemic Wister Rats. International Journal of Pharmacy and Pharmaceutical Studies, 7 (IV). pp. 1-13. ISSN 2457-0419

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Anaemia is a widespread blood condition characterised by a lack of red blood cells or a drop in haemoglobin levels, which results in decreased oxygen-carrying ability. It is a worldwide public health issue that affects people of all ages, genders, and socioeconomic situations. This study was aimed at analyzing and determining the proximate and phytochemical compositions of Mucuna pruriens and its antianaemic activities on male anaemic wister rats. healthy Mucuna pruriens leaves were harvested in Wukari, Taraba State, Nigeria. For ten days, the plant samples were shade dried. Using a mortar and pestle, the dry sample was reduced to powder. The coarse particles were sieved, yielding a fine powder. Extraction of M. pruriens was done by cold maceration with 100% methanol. Twenty (20) animals were grouped into four groups (n=5), anaemic control (group 1) was left untreated, standard control (group 2) received ferrous sulphate (75mg/kg body weight) while group 3 and 4 received 100mg/kg and 200mg/kg body weight methanolic extract of M. pruriens respectively, treatment lasted for 2 weeks and 5 days. Haematology auto analyser was used for haematological parameters. The results showed that M. pruriens, has high content of organic matter, moderate content of crude fibre, low ash content and much lower moisture and lipid contents. Saponin, tannins and glycosides where also present. There was a dose-dependent increase in packed cell volume (PCV), platelet, and Red blood cells (RBC) with significance of p < 0.05. There was no significant p > 0.05 difference in White blood cells (WBC), mean corpuscular hemoglobin (MCH), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), lymphocyte and neutrophil. There was a significant increase weight in groups treated with aqueous extract of M. prupriens as compared to groups untreated and standard control which reveal a reduction in weight of rats as compared to day one. The results suggest that M. pruriens plant is relatively safe and possesses a significant anti-anaemic property; therefore, it may be a potential lead in the discovery of drug for treatment of heamolytic anaemia.

Item Type: Article
Subjects: Q Science > QH Natural history > QH301 Biology
R Medicine > RA Public aspects of medicine
Divisions: Biological & Environmental Sciences (from Sep 19)
Publisher: Bharat Publication
Related URLs:
SWORD Depositor: A Symplectic
Date Deposited: 08 Feb 2024 10:53
Last Modified: 08 Feb 2024 11:00
URI: https://researchonline.ljmu.ac.uk/id/eprint/22545
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