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Trigeminal neuropathy presenting secondary to SARS-CoV-2 infection

O'Neill, F, De Stefano, G, Pridgeon, M, Bhargava, D, Marshall, A, Marshall, A and Frank, B (2023) Trigeminal neuropathy presenting secondary to SARS-CoV-2 infection. PAIN Reports, 8 (6). e1103. ISSN 2471-2531

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Introduction: A 58-year-old woman presented to a multidisciplinary facial pain clinic in October 2021 complaining of a constant pain in the right side of her face since contracting coronavirus SARS-CoV-2 18 months earlier. The pain extending from the right temple down to her right cheek extraorally and including the maxillary teeth and right side of tongue intraorally. This was accompanied by anosmia, diplopia on lateral gaze, and dizziness. Methods: Clinical examination was supplemented with several neurophysiological tests to confirm the diagnosis including an MRI brain scan, quantitative sensory testing, electrophysiological blink reflex testing, corneal confocal microscopy, and pain and short-form anxiety and depression questionnaires. Results: Quantitative sensory testing showed unilateral loss of perception in thermal and mechanical sensibility and bilateral hyperalgesia indicating central sensitization. Bilateral corneal confocal microscopy showed an abnormally reduced corneal nerve fibre length on the right side. MRI, blink reflex, and masseter inhibitory testing findings were normal. Conclusion: This case study is the first case of trigeminal neuropathy related to SARS-CoV-2 infection reported in the literature. It also discusses the successful management of the patient's trigeminal neuropathic pain.

Item Type: Article
Uncontrolled Keywords: Facial pain; Neuropathic; Pain
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Psychology (from Sep 2019)
Publisher: Lippincott, Williams & Wilkins
SWORD Depositor: A Symplectic
Date Deposited: 19 Feb 2024 15:44
Last Modified: 19 Feb 2024 15:45
DOI or ID number: 10.1097/pr9.0000000000001103
URI: https://researchonline.ljmu.ac.uk/id/eprint/22661
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