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Left ventricular strain-volume loops and myocardial fibrosis in pediatric patients with Duchenne muscular dystrophy

Kerstens, TP, van Everdingen, WM, Udink ten Cate, FEA and Thijssen, DHJ (2023) Left ventricular strain-volume loops and myocardial fibrosis in pediatric patients with Duchenne muscular dystrophy. International Journal of Cardiology, 395. pp. 1-5. ISSN 0167-5273

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Background: The left ventricular strain–volume loop (SVL) combines changes in global longitudinal strain (GLS) and LV volume across a cardiac cycle, providing insight into cardiac dynamics. This study explored the association between left ventricular SVL and presence of fibrosis, assessed with late gadolinium enhancement, in patients with Duchenne muscular dystrophy (DMD). Methods and results: 34 pediatric patients with DMD were included. Feature tracking analysis was used to assess endocardial GLS and volumetric measurements to construct the SVL. Mean age at the time of assessment was 14 ± 3 and 11 ± 2 years old (p < 0.01) in the group with (n = 18) versus without fibrosis (n = 16), respectively. Left ventricular ejection fraction was not significantly different between groups (fibrosis: 56.4 ± 3.8% versus without fibrosis: 54.0 ± 6.3%, p = 0.18). After adjusting for age, the late diastolic slope of the SVL was significantly associated with presence of fibrosis (OR 0.39 [95% CI 0.18–0.85]; area under the receiver operating characteristic curve: 0.83 [95% CI 0.70–0.97]) No significant association was observed for peak strain and fibrosis (OR 1.15 [95% CI 0.86–1.546]). Conclusion: A lower late diastolic slope of the left ventricular SVL, related to the interplay between longitudinal deformation and volume changes late in diastole, is associated with presence of myocardial fibrosis in pediatric patients with DMD.

Item Type: Article
Uncontrolled Keywords: Humans; Muscular Dystrophy, Duchenne; Cardiomyopathies; Ventricular Dysfunction, Left; Fibrosis; Gadolinium; Contrast Media; Magnetic Resonance Imaging, Cine; Stroke Volume; Ventricular Function, Left; Adolescent; Child; CMR; Duchenne muscular dystrophy; Myocardial fibrosis; Strain – volume loop; Humans; Child; Adolescent; Ventricular Dysfunction, Left; Contrast Media; Muscular Dystrophy, Duchenne; Magnetic Resonance Imaging, Cine; Gadolinium; Cardiomyopathies; Ventricular Function, Left; Stroke Volume; Fibrosis; 1102 Cardiorespiratory Medicine and Haematology; 1117 Public Health and Health Services; Cardiovascular System & Hematology
Subjects: R Medicine > RJ Pediatrics
Divisions: Sport & Exercise Sciences
Publisher: Elsevier
SWORD Depositor: A Symplectic
Date Deposited: 10 Apr 2024 13:09
Last Modified: 10 Apr 2024 13:15
DOI or ID number: 10.1016/j.ijcard.2023.131568
URI: https://researchonline.ljmu.ac.uk/id/eprint/23004
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