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Association of the MTHFR 1298A/C (rs1801131) polymorphism with speed and strength sports in Russian and Polish athletes

Zarebska, A, Ahmetov, II, Sawczyn, S, Weiner, AS, Kaczmarczyk, M, Ficek, K, Maciejewska-Karlowska, A, Sawczuk, M, Leonska-Duniec, A, Klocek, T, Voronina, EN, Boyarskikh, UA, Filipenko, ML and Cieszczyk, P (2013) Association of the MTHFR 1298A/C (rs1801131) polymorphism with speed and strength sports in Russian and Polish athletes. Journal of Sports Sciences, 32 (4). pp. 375-382. ISSN 0264-0414

The MTHFR 1298AC rs1801131 polymorphism is associated with speed and strength sports a study with two ethnic groups .pdf - Accepted Version
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It has been suggested that DNA hypomethylation because of poorer effectiveness of the 5,10-methylenetetrahydrofolate reductase (MTHFR) enzyme induces muscular growth. We hypothesised that the common, functional 1298A>C polymorphism in the MTHFR gene is associated with athletic status. To test this hypothesis, we investigated the distribution of the 1298A>C variant in Polish (n = 302) and Russian (n = 842) athletes divided into four groups: endurance, strength-endurance, sprint-strength and strength-endurance, as well as in 1540 control participants. We found different genotypes (the AC heterozygote advantage) and allele distributions among sprint-strength athletes and strength athletes than the groups of sedentary controls for each nationality. In the combined study, the allelic frequencies for the 1298C variant were 35.6% in sprint-strength athletes (OR 1.18 [1.02-1.36], P = 0.024 vs. controls) and 38.6% in strength athletes (OR 1.34 [1.10-1.64], P = 0.003 vs. controls). The results of the initial and repetition studies as well as the combined analysis suggest that the functional 1298A>C polymorphism in the MTHFR gene is associated with athletic status. The presence of the C allele seems to be beneficial in sprint-strength and strength athletes. It needs to be established whether and to what extent this effect is mediated by alteration in DNA methylation status.

Item Type: Article
Additional Information: This is an Accepted Manuscript of an article published by Taylor & Francis in Journal of Sports Sciences on September 9th 2013, available at: http://www.tandfonline.com//doi/full/10.1080/02640414.2013.825731
Uncontrolled Keywords: Science & Technology; Life Sciences & Biomedicine; Sport Sciences; DNA methylation; athletic ability; MTHFR; single nucleotide polymorphism; GENOMIC DNA METHYLATION; METHYLENETETRAHYDROFOLATE REDUCTASE GENE; COMMON MUTATION; MITOCHONDRIAL BIOGENESIS; HETEROZYGOTE ADVANTAGE; HOMOCYSTEINE LEVELS; C677T POLYMORPHISM; PROTEIN-METABOLISM; PHYSICAL-ACTIVITY; VASCULAR-DISEASE; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Odds Ratio; Case-Control Studies; Running; Gene Frequency; Genotype; Polymorphism, Single Nucleotide; Alleles; Sports; Poland; Russia; Female; Male; Muscle Strength; Young Adult; Athletes; White People; Alleles; Athletes; Case-Control Studies; Female; Gene Frequency; Genotype; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Muscle Strength; Odds Ratio; Poland; Polymorphism, Single Nucleotide; Running; Russia; Sports; White People; Young Adult; 1106 Human Movement and Sports Sciences; 1302 Curriculum and Pedagogy; Sport Sciences
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Taylor and Francis Group
SWORD Depositor: A Symplectic
Date Deposited: 02 May 2024 12:22
Last Modified: 02 May 2024 12:22
DOI or ID number: 10.1080/02640414.2013.825731
URI: https://researchonline.ljmu.ac.uk/id/eprint/23080
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