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Plant Antibacterials: The Challenges and Opportunities

Berida, TI, Adekunle, YA, Dada-Adegbola, H, Kdimy, A, Roy, S and Sarker, SD (2024) Plant Antibacterials: The Challenges and Opportunities. Heliyon. ISSN 2405-8440

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Abstract

Nature possesses an inexhaustible reservoir of agents that could serve as alternatives to combat the growing threat of antimicrobial resistance (AMR). While some of the most effective drugs for treating bacterial infections originate from natural sources, they have predominantly been derived from fungal and bacterial species. However, a substantial body of literature is available on the promising antibacterial properties of plant-derived compounds. In this comprehensive review, we address the major challenges associated with the discovery and development of plant-derived antimicrobial compounds, which have acted as obstacles preventing their clinical use. These challenges encompass limited sourcing, the risk of agent rediscovery, suboptimal drug metabolism, and pharmacokinetics (DMPK) properties, as well as a lack of knowledge regarding molecular targets and mechanisms of action, among other pertinent issues. Our review underscores the significance of these challenges and their implications in the quest for the discovery and development of effective plant-derived antimicrobial agents. Through a critical examination of the current state of research, we give valuable insights that will advance our understanding of these classes of compounds, offering potential solutions to the global crisis of AMR.

Item Type: Article
Subjects: Q Science > QH Natural history > QH301 Biology
R Medicine > RS Pharmacy and materia medica
R Medicine > RV Botanic, Thomsonian, and eclectic medicine
S Agriculture > SB Plant culture
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Elsevier
SWORD Depositor: A Symplectic
Date Deposited: 13 May 2024 11:08
Last Modified: 13 May 2024 11:15
DOI or ID number: 10.1016/j.heliyon.2024.e31145
URI: https://researchonline.ljmu.ac.uk/id/eprint/23239
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