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Plasma Biomarkers for Hypertension-Mediated Organ Damage Detection: A Narrative Review

Liu, X, Yang, M, Lip, GYH and McDowell, G (2024) Plasma Biomarkers for Hypertension-Mediated Organ Damage Detection: A Narrative Review. Biomedicines, 12 (5). p. 1071. ISSN 2227-9059

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Hypertension (HT) is a disease that poses a serious threat to human health, mediating organ damage such as the cardiovascular (CV) system, kidneys, central nervous system (CNS), and retinae, ultimately increasing the risk of death due to damage to the entire vascular system. Thus, the widespread prevalence of hypertension brings enormous health problems and socioeconomic burdens worldwide. The goal of hypertension management is to prevent the risk of hypertension-mediated organ damage and excess mortality of cardiovascular diseases. To achieve this goal, hypertension guidelines recommend accurate monitoring of blood pressure and assessment of associated target organ damage. Early identification of organ damage mediated by hypertension is therefore crucial. Plasma biomarkers as a non-invasive test can help identify patients with organ damage mediated by hypertension who will benefit from antihypertensive treatment optimization and improved prognosis. In this review, we provide an overview of some currently available, under-researched, potential plasma biomarkers of organ damage mediated by hypertension, looking for biomarkers that can be detected by simple testing to identify hypertensive patients with organ damage, which is of great significance in clinical work. Natriuretic peptides (NPs) can be utilized as a traditional biomarker to detect hypertension-mediated organ damage, especially for heart failure. Nevertheless, we additionally may need to combine two or more plasma biomarkers to monitor organ damage in the early stages of hypertension.

Item Type: Article
Uncontrolled Keywords: biomarker; hypertension; hypertension-mediated organ damage; hypertensive end-organ damage; plasma markers
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Nursing & Allied Health
Pharmacy & Biomolecular Sciences
Publisher: MDPI
SWORD Depositor: A Symplectic
Date Deposited: 05 Jun 2024 14:15
Last Modified: 05 Jun 2024 14:15
DOI or ID number: 10.3390/biomedicines12051071
URI: https://researchonline.ljmu.ac.uk/id/eprint/23426
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