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Severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters: pooled analysis of national prospective cohort studies of 30 million individuals in England, Northern Ireland, Scotland, and Wales

Agrawal, U, Bedston, S, McCowan, C, Oke, J, Patterson, L, Robertson, C, Akbari, A, Azcoaga-Lorenzo, A, Bradley, DT, Fagbamigbe, AF, Grange, Z, Hall, ECR, Joy, M, Katikireddi, SV, Kerr, S, Ritchie, L, Murphy, S, Owen, RK, Rudan, I, Shah, SA , Simpson, CR, Torabi, F, Tsang, RSM, de Lusignan, S, Lyons, RA, O'Reilly, D and Sheikh, A (2022) Severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters: pooled analysis of national prospective cohort studies of 30 million individuals in England, Northern Ireland, Scotland, and Wales. The Lancet, 400 (10360). pp. 1305-1320. ISSN 0140-6736

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Background Current UK vaccination policy is to offer future COVID-19 booster doses to individuals at high risk of serious illness from COVID-19, but it is still uncertain which groups of the population could benefit most. In response to an urgent request from the UK Joint Committee on Vaccination and Immunisation, we aimed to identify risk factors for severe COVID-19 outcomes (ie, COVID-19-related hospitalisation or death) in individuals who had completed their primary COVID-19 vaccination schedule and had received the first booster vaccine. Methods We constructed prospective cohorts across all four UK nations through linkages of primary care, RT-PCR testing, vaccination, hospitalisation, and mortality data on 30 million people. We included individuals who received primary vaccine doses of BNT162b2 (tozinameran; Pfizer–BioNTech) or ChAdOx1 nCoV-19 (OxfordAstraZeneca) vaccines in our initial analyses. We then restricted analyses to those given a BNT162b2 or mRNA-1273 (elasomeran; Moderna) booster and had a severe COVID-19 outcome between Dec 20, 2021, and Feb 28, 2022 (when the omicron (B.1.1.529) variant was dominant). We fitted time-dependent Poisson regression models and calculated adjusted rate ratios (aRRs) and 95% CIs for the associations between risk factors and COVID-19-related hospitalisation or death. We adjusted for a range of potential covariates, including age, sex, comorbidities, and previous SARS-CoV-2 infection. Stratified analyses were conducted by vaccine type. We then did pooled analyses across UK nations using f ixed-effect meta-analyses. Findings Between Dec 8, 2020, and Feb 28, 2022, 17 337 580 individuals completed their primary vaccine schedule and 14 698 030 individuals received a booster dose. Between Dec 20, 2021, and Feb 28, 2022, 59 510 (0·3%) of the primary vaccine group and 26 100 (0·2%) of those who received their booster had severe COVID-19 outcomes. The risk of severe COVID-19 outcomes reduced after receiving the booster (rate change: 8·8 events per 1000 personyears to 7·6 events per 1000 person-years). Older adults (≥80 years vs 18–49 years; aRR 3·60 [95% CI 3·45–3·75]), those with comorbidities (≥5 comorbidities vs none; 9·51 [9·07–9·97]), being male (male vs female; 1·23 [1·20–1·26]), and those with certain underlying health conditions—in particular, individuals receiving immunosuppressants (yes vs no; 5·80 [5·53–6·09])—and those with chronic kidney disease (stage 5 vs no; 3·71 [2·90–4·74]) remained at high risk despite the initial booster. Individuals with a history of COVID-19 infection were at reduced risk (infected ≥9 months before booster dose vs no previous infection; aRR 0·41 [95% CI 0·29–0·58]). Interpretation Older people, those with multimorbidity, and those with specific underlying health conditions remain at increased risk of COVID-19 hospitalisation and death after the initial vaccine booster and should, therefore, be prioritised for additional boosters, including novel optimised versions, and the increasing array of COVID-19 therapeutics. Funding National Core Studies–Immunity, UK Research and Innovation (Medical Research Council), Health Data Research UK, the Scottish Government, and the University of Edinburgh.

Item Type: Article
Uncontrolled Keywords: Humans; Immunosuppressive Agents; Immunization, Secondary; Vaccination; Prospective Studies; Aged; England; Northern Ireland; Scotland; Wales; Female; Male; COVID-19; SARS-CoV-2; COVID-19 Vaccines; BNT162 Vaccine; ChAdOx1 nCoV-19; Aged; BNT162 Vaccine; COVID-19; COVID-19 Vaccines; ChAdOx1 nCoV-19; England; Female; Humans; Immunization, Secondary; Immunosuppressive Agents; Male; Northern Ireland; Prospective Studies; SARS-CoV-2; Scotland; Vaccination; Wales; 11 Medical and Health Sciences; General & Internal Medicine
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
H Social Sciences > HV Social pathology. Social and public welfare. Criminology > HV697 Protection, assistance and relief
Divisions: Sport & Exercise Sciences
Publisher: Elsevier
SWORD Depositor: A Symplectic
Date Deposited: 07 Jun 2024 14:14
Last Modified: 07 Jun 2024 14:15
DOI or ID number: 10.1016/s0140-6736(22)01656-7
URI: https://researchonline.ljmu.ac.uk/id/eprint/23448
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