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The Ubiquinone-Ubiquinol Redox Cycle and Its Clinical Consequences: An Overview

Mantle, D, Dewsbury, MR and Hargreaves, IP (2024) The Ubiquinone-Ubiquinol Redox Cycle and Its Clinical Consequences: An Overview. International Journal of Molecular Sciences, 25 (12). ISSN 1661-6596

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Coenzyme Q10 (CoQ10) plays a key role in many aspects of cellular metabolism. For CoQ10 to function normally, continual interconversion between its oxidised (ubiquinone) and reduced (ubiquinol) forms is required. Given the central importance of this ubiquinone–ubiquinol redox cycle, this article reviews what is currently known about this process and the implications for clinical practice. In mitochondria, ubiquinone is reduced to ubiquinol by Complex I or II, Complex III (the Q cycle) re-oxidises ubiquinol to ubiquinone, and extra-mitochondrial oxidoreductase enzymes participate in the ubiquinone–ubiquinol redox cycle. In clinical terms, the outcome of deficiencies in various components associated with the ubiquinone–ubiquinol redox cycle is reviewed, with a particular focus on the potential clinical benefits of CoQ10 and selenium co-supplementation.

Item Type: Article
Uncontrolled Keywords: 0399 Other Chemical Sciences; 0604 Genetics; 0699 Other Biological Sciences; Chemical Physics
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: MDPI
SWORD Depositor: A Symplectic
Date Deposited: 27 Jun 2024 12:42
Last Modified: 27 Jun 2024 12:45
DOI or ID number: 10.3390/ijms25126765
URI: https://researchonline.ljmu.ac.uk/id/eprint/23649
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