Cucumeropsis mannii seed oil (CMSO) attenuates alterations in testicular biochemistry and histology against Bisphenol a-induced toxicity in male Wister albino rats

Agu, PC, Aja, PM ORCID: 0000-0001-7805-9027, Ekpono Ugbala, E, Ogwoni, HA, Ezeh, EM, Oscar-Amobi, PC, Asuk Atamgba, A, Ani, OG ORCID: 0000-0002-0986-8020, Awoke, JN, Nwite, FE, Ukachi, OU, Orji, OU, Nweke, PC, Ekpono Ugbala, E, Ewa, GO, Igwenyi, IO, Egwu, CO, Alum, EU ORCID: 0000-0003-4105-8615, Chukwu, DC and Famurewa, AC ORCID: 0000-0002-8795-9964 (2022) Cucumeropsis mannii seed oil (CMSO) attenuates alterations in testicular biochemistry and histology against Bisphenol a-induced toxicity in male Wister albino rats. Heliyon, 8 (3). pp. 1-9. ISSN 2405-8440

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Abstract

Background: Male reproductive health has deteriorated in recent years as a result of industrialization, which has led to the use of desirable chemicals, like Bisphenol A (BPA), of underlying toxicity. Cucumeropsis mannii seed is a common soup thickener that produces vegetable oil as well as essential nutrients making it a source of nutraceuticals enlisted with a wide range of therapeutic effects. Methods: A total of 48 adult male Wistar rats (120 200g) were used in this study. They were completely randomized and divided into six groups: A (1ml olive oil) irrespective of the weight, B [BPA 100 mg/kg body weight (bw)], C (CMSO 7.5 ml/kg bw), D (CMSO 7.5 ml/kg bw þ BPA 100 mg/kg bw), E (CMSO 5.0 ml/kg bw þ BPA 100 mg/kg bw), and E (CMSO 2.5 ml/kg bw þ BPA 100 mg/kg bw). At the end of the administration via oral routes, rats were sacrificed and testes were collected for biochemistry and histological analysis. Results: BPA significantly (P < 0.05) decreased total testicular protein, epididymal sperm parameters (count, volume, and motility), Mitochondrial Membrane Potential (MMP), body weight, testicular volume; and significantly (P < 0.05) increased testicular enzymes (alkaline phosphatase and lactate dehydrogenase), testicular index; plus histological damages. Interestingly, co-administration of BPA and CMSO significantly (P < 0.05) reversed the biochemical and histological changes. Conclusions: CMSO prevented the biochemistry and histological alterations hence reducing the testicular toxicity. Therefore, CMSO has the potential to be a promising novel nutraceutical for the treatment and management of BPA-induced testicular toxicity.

Item Type:	Article
Uncontrolled Keywords:	Bisphenol A; Cucumeropsis mannii; Nutraceuticals; Testicular toxicity; Contraception/Reproduction; Urologic Diseases; 3 Good Health and Well Being
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Pharmacy and Biomolecular Sciences
Publisher:	Elsevier
Date of acceptance:	18 March 2022
Date of first compliant Open Access:	29 November 2024
Date Deposited:	29 Nov 2024 13:23
Last Modified:	03 Jul 2025 17:30
DOI or ID number:	10.1016/j.heliyon.2022.e09162
URI:	https://researchonline.ljmu.ac.uk/id/eprint/24940

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