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Madangones A and B, two new neolignans from Beilschmiedia madang Blume and their bioactivities

Sarker, SD, Salleh, WMNHW, Ahmad, F, Yem, K and Zulkifli, MR (2016) Madangones A and B, two new neolignans from Beilschmiedia madang Blume and their bioactivities. Phytochemistry Letters, 15. pp. 168-173. ISSN 1876-7486

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Two new neolignans, madangones A (1) and B (2), together with (+)-kunstlerone (3), vanillin, vanillic acid, betulin, β-sitosterol and β-sitostenone, were isolated from the stem bark of Beilschmiedia madang (Lauraceae). The structures of the compounds were determined by spectroscopic means. The compounds were tested for antioxidant, acetylcholinesterase inhibitory and anti-inflammatory activities. Compound (3) displayed the strongest DPPH radical-scavenging activity with an IC50 value of 68.7 M. Compound (2) exhibited the highest level of activity on the COX-2 model and acetylcholinesterase inhibition assay, with IC50 values of 27.4 and 70.3 µM, respectively.

Item Type: Article
Uncontrolled Keywords: 0304 Medicinal And Biomolecular Chemistry, 0607 Plant Biology, 1115 Pharmacology And Pharmaceutical Sciences
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Elsevier
Date Deposited: 29 Jan 2016 16:06
Last Modified: 04 Sep 2021 13:32
URI: https://researchonline.ljmu.ac.uk/id/eprint/2788
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