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Adverse Outcome Pathways can drive non-animal approaches for safety assessment

Burden, N, Sewell, F, Andersen, ME, Boobis, A, Chipman, JK, Cronin, MTD, Hutchinson, TH, Kimber, I and Whelan, M (2015) Adverse Outcome Pathways can drive non-animal approaches for safety assessment. JOURNAL OF APPLIED TOXICOLOGY, 35 (9). pp. 971-975. ISSN 0260-437X

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Adverse Outcome Pathways (AOPs) provide an opportunity to develop new and more accurate safety assessment processes for drugs and other chemicals, and may ultimately play an important role in regulatory decision making. Not only can the development and application of AOPs pave the way for the development of improved evidence-based approaches for hazard and risk assessment, there is also the promise of a significant impact on animal welfare, with a reduced reliance on animal-based methods. The establishment of a useable and coherent knowledge framework under which AOPs will be developed and applied has been a first critical step towards realizing this opportunity. This article explores how the development of AOPs under this framework, and their application in practice, could benefit the science and practice of safety assessment, while in parallel stimulating a move away from traditional methods towards an increased acceptance of non-animal approaches. We discuss here the key areas where current, and future initiatives should be focused to enable the translation of AOPs into routine chemical safety assessment, and lasting 3Rs benefits.

Item Type: Article
Additional Information: © 2015 The Authors. Journal of Applied Toxicology published by John Wiley & Sons Ltd.
Uncontrolled Keywords: 1115 Pharmacology And Pharmaceutical Sciences
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
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Date Deposited: 02 Feb 2016 14:42
Last Modified: 23 May 2022 15:01
DOI or ID number: 10.1002/jat.3165
URI: https://researchonline.ljmu.ac.uk/id/eprint/2811
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