Nanotechnology-enhanced natural products for cancer chemoprevention: Molecular mechanisms and clinical translation

Nath, R, Kityania, S, Nath, D, Patra, JK, Habibi, E, Sarker, S ORCID: 0000-0003-4038-0514, Talukdar, AD and Nahar, L ORCID: 0000-0002-1157-2405 Nanotechnology-enhanced natural products for cancer chemoprevention: Molecular mechanisms and clinical translation. AAPS Journal. ISSN 1550-7416 (Accepted)

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Abstract

Cancer remains a major global health challenge. Natural compounds, such as curcumin, resveratrol, genistein, thymoquinone, and paclitaxel, show chemopreventive activity by modulating signaling pathways, including PI3K/Akt, NF-κB, and p53. These agents also promote apoptosis, autophagy, and DNA repair. However, their clinical use is restricted by poor solubility, instability, and low bioavailability. Nanotechnology offers solutions by improving stability, enhancing pharmacokinetics, and enabling targeted delivery. Liposomes, polymeric nanoparticles, dendrimers, and albumin-bound systems amplify the anticancer effects of natural compounds. Preclinical studies confirm improved efficacy, while early clinical trials reveal both promise and barriers. The key translational challenges include immune clearance, large-scale reproducibility, and regulatory approval. This review highlights the synergy between nanotechnology and natural compounds in cancer chemoprevention and outlines opportunities for future research.

Item Type:	Article
Uncontrolled Keywords:	1115 Pharmacology and Pharmaceutical Sciences; Pharmacology & Pharmacy; 3214 Pharmacology and pharmaceutical sciences
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RM Therapeutics. Pharmacology
Divisions:	Pharmacy and Biomolecular Sciences
Publisher:	Springer (American Association of Pharmaceutical Scientists)
Date of acceptance:	6 May 2026
Date Deposited:	08 May 2026 12:56
Last Modified:	08 May 2026 12:56
URI:	https://researchonline.ljmu.ac.uk/id/eprint/28536

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