Investigation of the Effect of Hydroalcoholic Extract Kelatin (Glaucium flavum) on Type 2 Diabetes: A randomized Double-Blind Clinical Trial

Deyri, G, Habibi, E ORCID: 0000-0002-7367-1484, Shirafkan, H, Lamooki, FM and Yousefi, SS (2025) Investigation of the Effect of Hydroalcoholic Extract Kelatin (Glaucium flavum) on Type 2 Diabetes: A randomized Double-Blind Clinical Trial. Advancements in Life Sciences: International Quarterly Journal of Biological Sciences, 12 (3). pp. 594-598. ISSN 2310-5380

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Abstract

Background: Diabetes is a chronic metabolic disease characterized by high blood glucose levels. It can be treated through diet, physical activity, and medication. Insulin and antidiabetic medications are commonly used, but alternative treatments such as medicinal plants have also been studied. kelatin with the scientific name of Glaucium flavum has chemical compounds of this plant including phytol, tricosan, 2-pentadecanone, and henicosan. As a result, sesquiterpene hydrocarbons were shown as the main group of the essential oils of the species. This study sought to determine the effects of Hydroalcoholic Extract Kelatin (Glaucium flavum) on Type 2 Diabetes.

Method: This is a randomized controlled clinical trial in which 66 diabetic patients were randomly divided into two groups. The experimental group patients received kelatin capsules for 60 days. Patients in control group received placebo capsules containing starch. Fasting blood sugar (FBS), hemoglobin A1c (HbA1c), insulin, high-density lipoprotein (HDL), low-density lipoprotein (LDL), Triglyceride, Cholesterol, Creatinine and Urea were measured before and after study

Results: The results of study show that, despite a significant decrease in FBS, HbA1c,Triglyceride, Cholesterol, HDL and Creatinine level before and after the study in experimental group, there were no significant difference in most variables between experimental and control group after intervention.

Conclusion: In this study there was no significant difference in most variables after intervention. This result could be due to small sample size.

Item Type:	Article
Uncontrolled Keywords:	32 Biomedical and Clinical Sciences; 3202 Clinical Sciences; Nutrition; Cardiovascular; Complementary and Integrative Health; Obesity; Diabetes; Atherosclerosis; Clinical Trials and Supportive Activities; Clinical Research; 6.1 Pharmaceuticals; Metabolic and endocrine
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Divisions:	Pharmacy and Biomolecular Sciences
Publisher:	The Running Line
Date of acceptance:	1 March 2025
Date of first compliant Open Access:	1 June 2026
Date Deposited:	01 Jun 2026 11:54
Last Modified:	01 Jun 2026 11:54
DOI or ID number:	10.62940/als.v12i3.3274
URI:	https://researchonline.ljmu.ac.uk/id/eprint/28695

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