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Taghipour, R, Hassannia, H, Arabnozari, H, Ehsan Enderami, S and Habibi, E 
ORCID: 0000-0002-7367-1484
(2025)
Natural Polysaccharides in Breast Cancer: Fucoidan’s Role in Enhancing Cisplatin Cytotoxicity and Reducing Chemotherapy Resistance.
In: Monteiro, AC and Wang, L, (eds.)
Latest Research on Breast Cancer - Molecular Insights, Diagnostic Advances and Therapeutic Innovations.
Oncology, 4
.
IntechOpen, London.
ISBN 978-0-85466-463-4
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Abstract
Cancer is one of the leading causes of death worldwide. Recent advancements in chemotherapy, particularly using natural drug-based strategies, have shown promise. This study evaluated the antitumor and anti-inflammatory effects of a combination of the brown alga Sargassum ilicifolium with cisplatin in vitro. After collecting and identifying the algae, fucoidan and alginate were extracted. The antioxidant activity was assessed using DPPH and Ferric Reducing Ability of Plasma (FRAP) assays. The cytotoxic effects on the MDA-MB-231 breast cancer cell line were evaluated in both 2D and 3D cultures using the XTT assay. Fucoidan and alginate yielded 7203 and 441 mg per 100 grams of dried algae, respectively. Total polysaccharide content in the fraction was estimated to be 89.39 mg/g dried algae weight. Fucoidan-rich extract exhibited higher antioxidant properties compared to alginate-rich extract. Also, the combination treatment significantly enhanced cytotoxicity, with the IC50 of fucoidan-rich extract reduced from 177.9 ± 8.7 to 79.3 ± 4.6 μg/ml in 2D culture when combined with cisplatin. In 3D culture, the IC50 decreased from over 800 ± 78.5 to 364.5 ± 41.7 μg/ml. Additionally, the fucoidan-rich extract significantly decreased IL-1β and IL-6 cytokine secretion in macrophages. These findings suggest combining cisplatin with fucoidan-rich extract enhances antitumor efficacy and may reduce chemotherapy side effects.
| Item Type: | Book Section |
|---|---|
| Uncontrolled Keywords: | 30 Agricultural, Veterinary and Food Sciences; 32 Biomedical and Clinical Sciences; 3211 Oncology and Carcinogenesis; Women's Health; Breast Cancer; Complementary and Integrative Health; Cancer; Cancer |
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Pharmacy and Biomolecular Sciences |
| Publisher: | IntechOpen |
| Date of acceptance: | 10 December 2024 |
| Date of first compliant Open Access: | 1 June 2026 |
| Date Deposited: | 01 Jun 2026 14:04 |
| Last Modified: | 01 Jun 2026 14:04 |
| DOI or ID number: | 10.5772/intechopen.1007395 |
| Editors: | Monteiro, AC and Wang, L |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/28696 |
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