Advancing next-generation risk assessment for cosmetic ingredients: transferring the 10-step read-across framework from human to environmental safety using triclosan as a case study

Streicher, H, Mishra, S, Naddi, Z, Fernandes, R, Autiero, M, Krause, S, Suri, AK, De Roy, C, Schepky, A and Najjar, A (2026) Advancing next-generation risk assessment for cosmetic ingredients: transferring the 10-step read-across framework from human to environmental safety using triclosan as a case study. NAM journal, 2. ISSN 3050-6204

Preview

Text 2026_Streicher et al., NGRA for cosmetic ingredients_triclosan.pdf - Published Version Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (9MB) | Preview

Abstract

Environmental risk assessment (ERA) has not yet undergone the shift toward new approach methodologies (NAMs), that has reshaped human health safety assessment. This study adapts the 10-step read across next generation risk assessment (NGRA) framework developed for cosmetic safety, to the environmental domain and applies it to triclosan (TCS), given its data richness and environmental relevance. The framework consists of three tiers: Tier 0 for problem formulation and <i>in silico</i> screening; Tier 1 for bioavailability estimation and mode of action hypothesis formulation; and Tier 2 for refinement, hazard characterisation, risk quantification and uncertainty assessment. Four core principles are proposed for environmental NGRA: the assessments should (1) be exposure-anchored, (2) be mechanism-based, (3) have translatable thresholds, and (4) be both protective and transparent. Exposure was assessed using a two-tier use-based predicted environmental concentration (PEC) approach. The lower tier applied a conservative aggregate cosmetic exposure scenario, yielding a screening PEC of 0.74 µg/L. This value exceeded both the ecological threshold of toxicological concern (ecoTTC) and Tier 0 read across thresholds, triggering refinement using year specific exposure data. Integrated bioactivity, QIVIVE and conservation analysis identified lipid and steroid metabolism as the most sensitive pathways. Tier 2 yielded two NGRA predicted no effect concentrations (PNECs): a species sensitivity distribution (SSD)-based PNEC of 0.020 µg/L and a lowest environmental point of departure (ePoD)-based PNEC of 0.007 µg/L. Risk characterisation ratios (RCRs) were below 1 from 2019 onwards under both routes, supporting an environmental NGRA approach at least as protective as conventional ERA. While the proposed framework has been demonstrated for an insecticide, this study extends it to a cosmetic ingredient, broadening the transferability of the 10-step framework for NAM-based ERA.

Item Type:	Article
Uncontrolled Keywords:	Cosmetics; Environmental risk assessment; In vitro to in vivo extrapolation; New approach methodologies; Next-generation risk assessment; Personal care products; Read-across; Triclosan; 4102 Ecological Applications; 41 Environmental Sciences; Prevention; 2.2 Factors relating to the physical environment; 14 Life Below Water
Subjects:	Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica
Divisions:	Pharmacy and Biomolecular Sciences
Publisher:	Elsevier
Date of acceptance:	26 June 2026
Date of first compliant Open Access:	16 July 2026
Date Deposited:	16 Jul 2026 14:50
Last Modified:	16 Jul 2026 14:50
DOI or ID number:	10.1016/j.namjnl.2026.100106
URI:	https://researchonline.ljmu.ac.uk/id/eprint/29022

View Item