New Approach Methodologies (NAMs) for Carcinogenicity Evaluation

Schorsch, F, Luijten, M, Cronin, M ORCID: 0000-0002-6207-4158, Ellinger-Ziegelbauer, H, Evans, K and Elloway, J (2026) New Approach Methodologies (NAMs) for Carcinogenicity Evaluation. Toxicologic Pathology, 54 (5). pp. 380-384. ISSN 0192-6233

Preview

Text Summary Proceedings New Approach Methodologies for Carcinogenicity for Symplectic.pdf - Accepted Version Available under License Creative Commons Attribution. Download (174kB) | Preview

Abstract

The second session of the 2nd Joint BSTP/ESTP Toxicologic Pathology Congress, Manchester, UK, September 23-26, 2025, entitled “New Approach Methodologies for Carcinogenicity Evaluation,” was dedicated to innovative strategies for assessing carcinogenic risks in various substances, particularly in drug development and agrochemicals. The two-year rodent cancer bioassay in two species (generally rats and mice) is currently the standard method for assessing the carcinogenic potential of agrochemicals for humans. However, this method has some weaknesses and is subject to ethical and scientific debate. Attempts to waive those studies have been proposed, but more relevant methods using less or preferably no animals are still being sought. The session featured five key presentations that explored cutting-edge methodologies aimed at improving the accuracy and reliability of carcinogenicity predictions. Below is a summary of each talk presented.

Item Type:	Article
Uncontrolled Keywords:	NAMs; 3Rs; risk assessment; carcinogenicity; Animals; Humans; Mice; Rats; Carcinogens; Risk Assessment; Carcinogenicity Tests; 3Rs; NAMs; carcinogenicity; risk assessment; Carcinogenicity Tests; Animals; Humans; Risk Assessment; Carcinogens; Mice; Rats; 3214 Pharmacology and Pharmaceutical Sciences; 32 Biomedical and Clinical Sciences; Cancer; Cancer; Carcinogenicity Tests; Animals; Humans; Risk Assessment; Carcinogens; Mice; Rats; 1103 Clinical Sciences; Toxicology; 3202 Clinical sciences
Subjects:	R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine > RA1190 Toxicology. Poisions R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions:	Sport and Exercise Sciences
Publisher:	SAGE Publications
Date of acceptance:	29 March 2026
Date of first compliant Open Access:	2 September 2026
Date Deposited:	01 Sep 2026 08:38
Last Modified:	02 Sep 2026 00:50
DOI or ID number:	10.1177/01926233261455035
URI:	https://researchonline.ljmu.ac.uk/id/eprint/29227

View Item