Isolation of flavonoids from the selected Trigonella species

Dogan, Z, Kaplan, O, Kilic, M, Nahar, L ORCID: 0000-0002-1157-2405 and Sarker, SD ORCID: 0000-0003-4038-0514 (2026) Isolation of flavonoids from the selected Trigonella species. Records of Natural Products, 20 (6). ISSN 1307-6167

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Abstract

Trigonella foenum-graecum, a plant cultivated in Türkiye, is used as fodder, food, spice, perfume, insect repellent, dye, and for medicinal applications. While there are numerous studies on this species in the literature, detailed investigations of some endemic species widely grown in Türkiye are lacking.The phytochemical studies on T.foenum-graecum and Türkiye’s endemic species, T. macrorrhyncha and T. kotschyi, were conducted, affording 11 compounds, including three previously undescribed compounds, from aqueous extracts of aerial parts of the endemic species and T. foenum-graecum.The isolated newc ompounds were conclusively identified as quercetin 3-O-(2′′-O-β-glucosyl-6′′-O-acetyl)-β-galactoside 7-O-β-glucoside (3), kaempferol 3-O-(2′′-O-(4′′′-O-malonyl)-α-rhamnosyl)-β-glucoside) 7-O-α-rhamnoside (10) and kaempferol 3-O-(2′′-O-(4′′′-O-methylmalonyl)-α-rhamnosyl)β-glucoside) 7-O-α-rhamnoside (11). Cytotoxic activity of the extracts and the isolated compounds from the active extract was also tested on A549 and PC3 cancer cell lines. Cite this article as: Doganetal. Isolation of flavonoids from the selected Trigonella species. (2026). Records of Natural Products, 20(6):e26043782 Received: 07 April 2026 Revised: 11 June 2026 Accepted: 13 June 2026 Published: 23 June 2026 Although the T. kotschyi extract demonstrated moderate cytotoxicity (IC50: 75.54 and 64.14 μg/mL for A549 and PC-3, respectively), none of the isolated compounds exhibited notable cytotoxicity.

Item Type:	Article
Uncontrolled Keywords:	Fabaceae; Trigonella; fenugreek; quercetin; kaempferol-glycosides; 30 Agricultural, Veterinary and Food Sciences; 31 Biological Sciences; 3006 Food Sciences; Cancer; Complementary and Integrative Health; Nutrition; Dietary Supplements
Subjects:	R Medicine > RS Pharmacy and materia medica R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions:	Pharmacy and Biomolecular Sciences
Publisher:	ACG Publications
Date of acceptance:	13 June 2026
Date of first compliant Open Access:	4 September 2026
Date Deposited:	04 Sep 2026 08:15
Last Modified:	04 Sep 2026 08:15
DOI or ID number:	10.25135/rnp.2604.3782
URI:	https://researchonline.ljmu.ac.uk/id/eprint/29321

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