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Stachowiak, W 
ORCID: 0000-0002-6484-4507, Wysocki, M ORCID: 0000-0003-3585-2716, Guazzelli, L ORCID: 0000-0003-4655-2946 and Niemczak, M ORCID: 0000-0002-4364-8267
(2025)
Glycine Betaine-Functionalized Ionic Liquids: Design of Versatile Bioplatform for Incorporating Biologically Active Moieties into Cations.
ACS Medicinal Chemistry Letters, 16 (9).
pp. 1756-1761.
ISSN 1948-5875
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Abstract
We report a novel series of ILs formed by coupling glycine betaine with the biologically active herbicide MCPA via an ester bond. ILs were synthesized through a 2-step O-alkylation process, followed by product isolation using flash chromatography. The alkyl chain length between the carboxylic groups determines solubility and octanol–water partition coefficient, whereas the rate of their hydrolysis is highly influenced by the pH of aqueous solution. All compounds retained the biological activity of the incorporated herbicide.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Glycine Betaine; Functionalized Ionic Liquids; Biologically Active; Design of Versatile Bioplatform; Cations; Biologically Active; Cations; Design of Versatile Bioplatform; Functionalized Ionic Liquids; Glycine Betaine; 3405 Organic Chemistry; 34 Chemical Sciences; 0304 Medicinal and Biomolecular Chemistry; 0305 Organic Chemistry; 1115 Pharmacology and Pharmaceutical Sciences; 3404 Medicinal and biomolecular chemistry; 3405 Organic chemistry |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Pharmacy and Biomolecular Sciences |
| Publisher: | American Chemical Society |
| Date of acceptance: | 8 August 2025 |
| Date of first compliant Open Access: | 15 September 2026 |
| Date Deposited: | 15 Sep 2026 07:42 |
| Last Modified: | 15 Sep 2026 07:42 |
| DOI or ID number: | 10.1021/acsmedchemlett.5c00280 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/29414 |
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