A systematic review and meta-analysis of randomized controlled trials examining the effect of ultra-processed food on energy intake and weight gain

Robinson, E, Jones, A ORCID: 0000-0001-5951-889X, Evans, R, Finlay, A, Brealey, J, Gough, T, Cummings, J, Fisher, E, Jutla, M, Morenikeji Ibilola, E and Norton, V (2026) A systematic review and meta-analysis of randomized controlled trials examining the effect of ultra-processed food on energy intake and weight gain. Critical Reviews in Food Science and Nutrition. pp. 1-16. ISSN 1040-8398

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Abstract

Ultra-processed food (UPF) may contribute to increased energy intake and weight gain, but evidence synthesis from randomized controlled trials (RCT) is lacking. A pre-registered systematic review and meta-analysis of RCTs was conducted comparing UPF with less processed food (LPF) on energy intake and/or body weight in humans. Secondary analyses (meta-regression and sub-group) examined effects of UPF on appetite sensations, eating rate, palatability and considered the role of nutrient profile in explaining results. Ten eligible studies were included. UPF trial arms tended to have higher energy intake (standardized mean differences [SMDs] = 0.18-0.44), but statistical significance varied between analytic models. Weight gain (SMD = 0.65) and eating rate (SMD = 0.96) were significantly greater in UPF trial arms. No significant differences in palatability, appetite sensations or energy intake later in the day were observed. Diets (UPF vs. LPF) used in trials were not matched for nutrient profile. Effects on energy intake varied if UPF diets were higher (SMD = 0.71) or similar (SMD = 0.02) in energy density than LPF diets. UPFs may increase energy intake and body weight, although results may be explained by energy density of foods used in RCTs to date and evidential certainty is low. Further research is needed to understand whether level of ultra-processing impacts health outcomes independent to nutrient profile.

Item Type:	Article
Uncontrolled Keywords:	0702 Animal Production; 0908 Food Sciences; 1111 Nutrition and Dietetics; Nutrition & Dietetics; 3006 Food sciences; 3210 Nutrition and dietetics
Subjects:	B Philosophy. Psychology. Religion > BF Psychology T Technology > TX Home economics > TX341 Nutrition. Foods and food supply
Divisions:	Psychology (from Sep 2019)
Publisher:	Taylor & Francis
Date of acceptance:	7 July 2026
Date of first compliant Open Access:	16 September 2026
Date Deposited:	16 Sep 2026 09:59
Last Modified:	16 Sep 2026 09:59
DOI or ID number:	10.1080/10408398.2026.2731838
URI:	https://researchonline.ljmu.ac.uk/id/eprint/29442

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