Distribution, biosynthesis, laboratory synthesis, and therapeutic potential of derrone: A narrative review

Sarker, S ORCID: 0000-0003-4038-0514, Abdelfattah, JMM, Habibi, E ORCID: 0000-0002-7367-1484, Kaewpradit, S, Ritchie, KJ ORCID: 0000-0002-8504-6918 and Nahar, L ORCID: 0000-0002-1157-2405 (2026) Distribution, biosynthesis, laboratory synthesis, and therapeutic potential of derrone: A narrative review. Phytochemistry Letters, 76. ISSN 1874-3900

Preview

Text Distribution, biosynthesis, laboratory synthesis, and therapeutic potential of derrone- A narrative review.pdf - Published Version Available under License Creative Commons Attribution. Download (921kB) | Preview

Abstract

Derrone is a naturally occurring pyranoisoflavone, first isolated from the seeds of Derris robusta (Roxb. ex DC.) Benth. of the family Fabaceae, and subsequently reported from several additional species, predominantly within the Fabaceae and Moraceae families. This narrative review provides an overview of derrone, including its distribution across the plant kingdom, biosynthetic origin, laboratory synthesis, and documented bioactivities relevant to its potential therapeutic applications. Peer-reviewed publications on derrone published to date, excluding any doctoral theses or conference abstracts, were examined. Relevant information was obtained from various databases, including Web of Science, ScienceDirect, PubMed, and Google Scholar, using “derrone” as the sole keyword. Published studies have reported the antidiabetic, antifibrotic, antimicrobial, antiplatelet, antithrombotic, antitumour, cytotoxic/anticancer, hepatoprotective, and anti-HIV-1 properties of derrone, with the most therapeutically significant evidence relating to its anticancer, antidiabetic, antiplatelet, and antitumour properties. Nevertheless, further rigorous investigations are required to substantiate the therapeutic potential of derrone in human diseases.

Item Type:	Article
Uncontrolled Keywords:	0304 Medicinal and Biomolecular Chemistry; 0607 Plant Biology; 1115 Pharmacology and Pharmaceutical Sciences; Medicinal & Biomolecular Chemistry; 3404 Medicinal and biomolecular chemistry; 3405 Organic chemistry
Subjects:	R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica
Divisions:	Pharmacy and Biomolecular Sciences
Publisher:	Elsevier
Date of acceptance:	24 September 2026
Date of first compliant Open Access:	29 September 2026
Date Deposited:	29 Sep 2026 12:03
Last Modified:	29 Sep 2026 12:03
URI:	https://researchonline.ljmu.ac.uk/id/eprint/29553

View Item