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Al-Majmaie, S, Nahar, L, Rahman, MM, Sharples, GP 
ORCID: 0000-0003-0492-0253, Arabnozari, H and Sarker, SD ORCID: 0000-0003-4038-0514
(2026)
Anti-methicillin-resistant Staphylococcus aureus (Anti-MRSA) flavonoids from Iraqi Citrus sinensis (L.) Osbeck.
Scientific Reports.
ISSN 2045-2322
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Abstract
Citrus sinensis (L.) Osbeck (Rutaceae) was investigated as a potential source of anti-MRSA compounds. A bioassay-guided isolation approach afforded fourteen compounds from the peel and leaf extracts of C. sinensis, including a new flavanone glycoside, sinensidin (10). Structural elucidation was based on spectroscopic analyses, including 1D and 2D NMR and HRMS data. Among the isolated compounds, 3-methoxynobiletin (4), sinensetin (7), and rutin 3′-methyl ether (12) exhibited moderate anti-MRSA activity (MIC = 128–256 µg/mL). The crude extract showed higher apparent activity than the individual compounds, suggesting possible contributions from additional constituents and/or synergistic interactions. This study expands the phytochemical profile of C. sinensis and suggests that its polymethoxylated flavonoids and flavonoid glycosides may contribute to anti-MRSA activity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 30 Agricultural, Veterinary and Food Sciences; 32 Biomedical and Clinical Sciences; 3006 Food Sciences; Emerging Infectious Diseases; Dietary Supplements; Complementary and Integrative Health; Antimicrobial Resistance; Infectious Diseases |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Pharmacy and Biomolecular Sciences |
| Publisher: | Nature |
| Date of acceptance: | 31 August 2026 |
| Date of first compliant Open Access: | 5 October 2026 |
| Date Deposited: | 05 Oct 2026 13:33 |
| Last Modified: | 05 Oct 2026 13:33 |
| DOI or ID number: | 10.1038/s41598-026-69806-7 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/29604 |
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