Effect of lactational low-protein diet on skeletal muscle during adulthood and ageing in male and female mouse offspring

Export Citation

Alameddine, M, Altinpinar, AE, Ersoy, U, Kanakis, I, Myrtziou, I and Ozanne, SE (2024) Effect of lactational low-protein diet on skeletal muscle during adulthood and ageing in male and female mouse offspring. Nutrients, 16 (17). ISSN 2072-6643

[thumbnail of Effect of lactational low-protein diet on skeletal muscle during adulthood and ageing in male and female mouse offspring.pdf]
Preview
 Text
Effect of lactational low-protein diet on skeletal muscle during adulthood and ageing in male and female mouse offspring.pdf - Published Version
Available under License Creative Commons Attribution.
Download (3MB) | Preview

Abstract

Sarcopenia is characterised by the loss of skeletal muscle mass and function, which leads to a high risk of increased morbidity and mortality. Maternal malnutrition has been linked to impaired development of skeletal muscle of the offspring; however, there are limited studies that report the long-term effect of a maternal low-protein diet during lactation on the ageing of skeletal muscles. This study aimed to examine how a maternal low-protein diet (LPD) during lactation affects skeletal muscle ageing in the offspring. Pups born from control mothers were lactated by mothers fed with an LPD. Post-weaning, mice were either maintained on an LPD or switched to a control, normal-protein diet (NPD). In males, an LPD mainly affected the size of the myofibres without a major effect on fibre number and led to reduced grip strength in ageing mice (24 months). Female mice from mothers on an LPD had a lower body and muscle weight at weaning but caught up with control mice at 3 months. During ageing, the muscle weight, myofibre number and survival rate of female pups were significantly affected. These findings highlight the effect of an LPD during lactation on skeletal muscle ageing, the lifespan of offspring and the importance of sexual dimorphism in response to dietary challenges.

Item Type: Article
Uncontrolled Keywords: low-protein diet (LPD); skeletal muscle; ageing; lactation; sarcopenia; Muscle, Skeletal; Animals; Mice, Inbred C57BL; Mice; Diet, Protein-Restricted; Weaning; Aging; Lactation; Female; Male; Maternal Nutritional Physiological Phenomena; Sarcopenia; ageing; lactation; low-protein diet (LPD); sarcopenia; skeletal muscle; Animals; Female; Muscle, Skeletal; Lactation; Diet, Protein-Restricted; Male; Aging; Mice; Maternal Nutritional Physiological Phenomena; Weaning; Sarcopenia; Mice, Inbred C57BL; 32 Biomedical and Clinical Sciences; 3210 Nutrition and Dietetics; 3202 Clinical Sciences; Women's Health; Aging; Nutrition; Breastfeeding, Lactation and Breast Milk; Prevention; Pediatric Research Initiative; 1.1 Normal biological development and functioning; Musculoskeletal; Reproductive health and childbirth; 2 Zero Hunger; Animals; Female; Muscle, Skeletal; Lactation; Diet, Protein-Restricted; Male; Aging; Mice; Maternal Nutritional Physiological Phenomena; Weaning; Sarcopenia; Mice, Inbred C57BL; 0908 Food Sciences; 1111 Nutrition and Dietetics; 3202 Clinical sciences; 3210 Nutrition and dietetics; 4206 Public health
Subjects: T Technology > TX Home economics > TX341 Nutrition. Foods and food supply
Q Science > QL Zoology
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy and Biomolecular Sciences
Publisher: MDPI AG
Date of acceptance: 26 August 2024
Date of first compliant Open Access: 9 October 2026
Date Deposited: 09 Oct 2026 14:32
Last Modified: 09 Oct 2026 14:40
DOI or ID number: 10.3390/nu16172926
URI: https://researchonline.ljmu.ac.uk/id/eprint/29642
View Item View Item
CORE (COnnecting REpositories)