Versatile Porphyrin Arrangements for Photodynamic Therapy—A Review

Glowacka-Sobotta, A, Czarczynska-Goslinska, B ORCID: 0000-0001-8654-7987, Ziental, D ORCID: 0000-0002-4923-9982, Wysocki, M ORCID: 0000-0003-3585-2716, Michalak, M ORCID: 0009-0005-1077-1671, Güzel, E ORCID: 0000-0002-1142-3936 and Sobotta, L ORCID: 0000-0002-5062-4503 (2024) Versatile Porphyrin Arrangements for Photodynamic Therapy—A Review. Nanomaterials, 14 (23). ISSN 2079-4991

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Abstract

Nanotechnology is an emerging field that involves the development of nanoscale particles, their fabrication methods, and potential applications. From nanosized inorganic particles to biopolymers, the variety of nanoparticles is unstoppably growing, offering huge opportunities for drug delivery. Various nanoformulations, such as nanoparticles, nanocomposites, and nanoemulsions, have been developed to enhance drug stability, solubility, and tissue penetration. Moreover, nanocarriers can be specifically engineered to target diseased cells or release the drug in a controllable manner, minimizing damage to surrounding healthy tissues and reducing side effects. This review focuses on the combinations between porphyrin derivatives and nanocarriers applied in photodynamic therapy (PDT). PDT has emerged as a significant advance in medicine, offering a low-invasive method for managing infections, the treatment of tumors, and various dermatoses. The therapy relies on the activation of a photosensitizer by light, which results in the generation of reactive oxygen species. Despite their favorable properties, porphyrins reveal non-specific distribution within the body. Nanotechnology has the capability to enhance the PS delivery and its activation. This review explores the potential improvements that are provided by the use of nanotechnology in the PDT field.

Item Type:	Article
Uncontrolled Keywords:	PDT; PACT; porphyrin; nanotechnology; bacterial infections; chlorin e6; bacteriochlorin; isobacteriochlorin; PACT; PDT; bacterial infections; bacteriochlorin; chlorin e6; isobacteriochlorin; nanotechnology; porphyrin; 40 Engineering; 4018 Nanotechnology; Nanotechnology; Bioengineering; Cancer; Radiation Oncology; Biotechnology; 0912 Materials Engineering; 1007 Nanotechnology; 4016 Materials engineering; 4018 Nanotechnology
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Pharmacy and Biomolecular Sciences
Publisher:	MDPI
Date of acceptance:	19 November 2024
Date of first compliant Open Access:	15 October 2026
Date Deposited:	15 Oct 2026 12:20
Last Modified:	15 Oct 2026 12:20
DOI or ID number:	10.3390/nano14231879
URI:	https://researchonline.ljmu.ac.uk/id/eprint/29686

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