Histamine Metabolism in IBD: Towards Precision Nutrition

Kanta, D ORCID: 0009-0001-8212-4853, Katsamakas, E, Gudiksen, AMB and Jalili, M ORCID: 0000-0001-7825-9483 (2025) Histamine Metabolism in IBD: Towards Precision Nutrition. Nutrients, 17 (15). ISSN 2072-6643

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Abstract

Patients with Inflammatory Bowel Disease (IBD) exhibit a dysregulated immune response that may be further exacerbated by bioactive compounds, such as histamine. Current dietary guidelines for IBD primarily focus on symptom management and flare-up prevention, yet targeted nutritional strategies addressing histamine metabolism remain largely unexplored. This narrative review aims to summarize the existing literature on the complex interplay between IBD and histamine metabolism and propose a novel dietary framework for managing IBD progression in patients with histamine intolerance (HIT). Relevant studies were identified through a comprehensive literature search of PubMed/MEDLINE, Google Scholar, ScienceDirect, Scopus, and Web of Science. The proposed low-histamine diet (LHD) aims to reduce the overall histamine burden in the body through two primary strategies: (1) minimizing exogenous intake by limiting high-histamine and histamine-releasing foods and (2) reducing endogenous histamine production by modulating gut microbiota composition, specifically targeting histamine-producing bacteria. In parallel, identifying individuals who are histamine-intolerant and understanding the role of histamine-degrading enzymes, such as diamine oxidase (DAO) and histamine-N-methyltransferase (HNMT), are emerging as important areas of focus. Despite growing interest in the role of histamine and mast cell activation in gut inflammation, no clinical trials have investigated the effects of a low-histamine diet in IBD populations. Therefore, future research should prioritize the implementation of LHD interventions in IBD patients to evaluate their generalizability and clinical applicability.

Item Type:	Article
Uncontrolled Keywords:	histamine; IBD; Crohn's disease; ulcerative colitis; low-histamine diet; histamine intolerance; DAO; mast cell activation; histamine-producing bacteria; nutrition; Crohn’s disease; DAO; IBD; histamine; histamine intolerance; histamine-producing bacteria; low-histamine diet; mast cell activation; nutrition; ulcerative colitis; Humans; Histamine; Inflammatory Bowel Diseases; Gastrointestinal Microbiome; Precision Medicine; Diet; 32 Biomedical and Clinical Sciences; 3210 Nutrition and Dietetics; Digestive Diseases; Inflammatory Bowel Disease; Microbiome; Dietary Supplements; Autoimmune Disease; Prevention; Crohn's Disease; Nutrition; Oral and gastrointestinal; Humans; Histamine; Inflammatory Bowel Diseases; Gastrointestinal Microbiome; Precision Medicine; Diet; 0908 Food Sciences; 1111 Nutrition and Dietetics; 3202 Clinical sciences; 3210 Nutrition and dietetics; 4206 Public health
Subjects:	T Technology > TX Home economics > TX341 Nutrition. Foods and food supply R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions:	Sport and Exercise Sciences
Publisher:	MDPI
Date of acceptance:	24 July 2025
Date of first compliant Open Access:	15 October 2026
Date Deposited:	15 Oct 2026 12:26
Last Modified:	15 Oct 2026 12:26
DOI or ID number:	10.3390/nu17152473
URI:	https://researchonline.ljmu.ac.uk/id/eprint/29687

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