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Jones, H, Cable, NT, Aziz, N, Dobson, R, Sprung, VS, Low, DA and Bailey, TG (2016) EXERCISE TRAINING REDUCES THE FREQUENCY OF MENOPAUSAL HOT FLUSHES BY IMPROVING THERMOREGULATORY CONTROL. Menopause: The Journal of the North American Menopause Society, 23 (7). pp. 708-718. ISSN 1530-0374

ExerciseTrainingReducesHotFlushes_MenopauseSubmission_for deposit.pdf - Accepted Version

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Objectives: Post-menopausal hot flushes occur due to a reduction in oestrogen production causing thermoregulatory and vascular dysfunction. Exercise training enhances thermoregulatory control of sweating, skin and brain blood flow. We aimed to determine if improving thermoregulatory control and vascular function with exercise training alleviated hot flushes. Methods: Twenty one symptomatic females completed a 7-day hot flush questionnaire and underwent brachial artery flow-mediated dilation and a cardiorespiratory fitness test. Sweat rate and skin blood flow temperature thresholds and sensitivities, and middle cerebral artery velocity (MCAv) was measured during passive heating. Females performed 16-weeks of supervised exercise training or control, and measurements were repeated. Results: There was a greater improvement in cardiorespiratory fitness (4.45 ml•kg-1•min-1 (95% CI: 1.87, 8.16; P=0.04) and reduced hot flush frequency [48 hot flushes•week (39, 56) P<0.001] following exercise compared to control. Exercise reduced basal core temperature [0.14°C (0.01, 0.27) P=0.03] and increased basal MCAv [2.8 cm/s (1.0 to 5.2) P=0.04] compared to control. Sweat rate and skin blood flow thresholds occurred ~0.19 and 0.17°C earlier, alongside improved sweating sensitivity with exercise. MCAv decreased during heating [P<0.005], but was maintained 4.5 cm/s (3.6, 5.5 P<0.005) higher during heating following exercise compared to control [0.6 cm/s (-0.4, 1.4)]. Conclusions: Exercise training that improves cardiorespiratory fitness reduces self-reported hot flushes. Improvements are likely mediated through greater thermoregulatory control in response to increases in core temperature and enhanced vascular function in the cutaneous and cerebral circulations.

Item Type: Article
Additional Information: This is the accepted version of the following article: Bailey, Tom G. PhD; Cable, N. Timothy PhD; Aziz, Nabil MD; Dobson, Rebecca MD; Sprung, Victoria S. PhD; Low, David A. PhD; Jones, Helen PhD Exercise training reduces the frequency of menopausal hot flushes by improving thermoregulatory control Menopause. 23(7):708-718, July 2016., which has been published in final form at http://dx.doi.org/10.1097/GME.0000000000000625.
Uncontrolled Keywords: 11 Medical And Health Sciences
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Lippincott, Williams &amp; Wilkins
Date Deposited: 09 Mar 2016 13:57
Last Modified: 04 Sep 2021 13:16
DOI or ID number: 10.1097/GME.0000000000000625
URI: https://researchonline.ljmu.ac.uk/id/eprint/3129
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