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Amorphism and Thermal Decomposition of Salicylsalicylic Acid—A Cautionary Tale

Aguilar, JA, Ball, AT, Coxon, CR, Kenwright, AM, Lancaster, RW, Mosely, JA and Mutton, MA (2016) Amorphism and Thermal Decomposition of Salicylsalicylic Acid—A Cautionary Tale. Journal of Pharmaceutical Sciences, 105 (10). pp. 3017-3078. ISSN 0022-3549

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Salicylsalicylic acid (“Salsalate”) is a non-steroidal anti-inflammatory drug with anti-rheumatic properties, whose amorphous form offers the potential for enhanced dissolution rates and improved bioavailability compared with its crystalline counterpart. It has been reported to form a stable glassy phase on heating and rapid quenching. A number of the existing studies of the solid-state structure of salsalate and of its thermal decomposition contain information that is difficult to reconcile. In this article, we review much of the existing literature in light of our own recent studies using solution-state nuclear magnetic resonance, mass spectrometry, and solid-state infrared spectroscopy, and conclude that much of the literature data relating to melting and the glassy state is questionable due to failure to take into account the effects of thermal decomposition. © 2016 American Pharmacists Association®

Item Type: Article
Uncontrolled Keywords: 1115 Pharmacology And Pharmaceutical Sciences
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Elsevier
Date Deposited: 06 Oct 2016 08:59
Last Modified: 20 Apr 2022 10:24
DOI or ID number: 10.1016/j.xphs.2016.06.009
URI: https://researchonline.ljmu.ac.uk/id/eprint/4257
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