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The pH Dependent Interaction between Nicotine and Simulated Pulmonary Surfactant Monolayers with Associated Molecular Modelling

Davies, MJ, Leach, AG, Fullwood, DL, Mistry, D and Hope, A (2017) The pH Dependent Interaction between Nicotine and Simulated Pulmonary Surfactant Monolayers with Associated Molecular Modelling. Surface and Interface Analysis. ISSN 1096-9918

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Pulmonary surfactant is an endogenous material that lines and stabilises the alveolar air-liquid interface. Respiratory mechanics can be compromised by exposure to environmental toxins such as cigarette vapour, which contains nicotine. This study aims to determine the influence of nicotine on the activity of simulated lung surfactant at pH 7 and pH 9. In all cases, the addition of nicotine to the test zone caused deviation in surfactant film performance. Importantly, the maximum surface pressure was reduced for each system. Computational modelling was applied to assess key interactions between each species, with the Gaussian 09 software platform used to calculate electrostatic potential surfaces. Modelling data confirmed either nicotine penetration into the two-dimensional structure or interfacial / electrostatic interactions across the underside. The results obtained from this study suggest that nicotine can impair the ability of pulmonary surfactant to reduce the surface tension term, which can increase the work of breathing. When extrapolated to gross lung function alveolar collapse and respiratory disease (e.g. chronic airway obstruction) may result. The delivery of nicotine to the (deep) lung can cause a deterioration in lung function and lead to reduced quality of life.

Item Type: Article
Additional Information: This is the accepted version of the following article: Davies, M. J., Leach, A. G., Fullwood, D., Mistry, D., and Hope, A. (2017) The pH dependent interaction between nicotine and simulated pulmonary surfactant monolayers with associated molecular modelling. Surf. Interface Anal., doi: 10.1002/sia.6244, which has been published in final form at http://dx.doi.org/10.1002/sia.6244
Uncontrolled Keywords: 0306 Physical Chemistry (Incl. Structural), 0204 Condensed Matter Physics
Subjects: Q Science > QD Chemistry
R Medicine > R Medicine (General)
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Wiley
Date Deposited: 25 Apr 2017 09:59
Last Modified: 04 Sep 2021 11:42
DOI or ID number: 10.1002/sia.6244
URI: https://researchonline.ljmu.ac.uk/id/eprint/6281
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