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Effects of Exercise on Vascular Function, Structure, and Health in Humans.

Green, DJ and Smith, KJ (2017) Effects of Exercise on Vascular Function, Structure, and Health in Humans. Cold Spring Harbor Perspectives in Medicine. ISSN 2157-1422

Cold Spring Harb Perspect Med-2017-Green-cshperspect.a029819.pdf - Published Version

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Physical activity has profound impacts on the vasculature in humans. Acute exercise induces immediate changes in artery function, whereas repeated episodic bouts of exercise induce chronic functional adaptation and, ultimately, structural arterial remodeling. The nature of these changes in function and structure are dependent on the characteristics of the training load and may be modulated by other factors such as exercise-induced inflammation and oxidative stress. The clinical implications of these physiological adaptations are profound. Exercise impacts on the development of atherosclerosis and on the incidence of primary and secondary cardiovascular events, including myocardial infarction and stroke. Exercise also plays a role in the amelioration of other chronic diseases that possess a vascular etiology, including diabetes and dementia. The mechanisms responsible for these effects of exercise on the vasculature are both primary and secondary in nature, in that the benefits conferred by changes in cardiovascular risk factors such as lipid profiles and blood pressure occur in concert with direct effects of arterial shear stress and mechanotransduction. From an evolutionary perspective, exercise is an essential stimulus for the maintenance of vascular health: exercise is vascular medicine.

Item Type: Article
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Cold Harbor Laboratory Press
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Date Deposited: 25 May 2017 08:36
Last Modified: 04 Sep 2021 11:40
DOI or ID number: 10.1101/cshperspect.a029819
URI: https://researchonline.ljmu.ac.uk/id/eprint/6302
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