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The Effects of Cinnamon Supplementation on Plasma Lipid Concentrations: A Systematic Review and Meta-Analysis

Maierean, S, Serban, MC, Sahebkar, A, Ursoniu, S, Serban, A, Penson, P and Banach, M (2017) The Effects of Cinnamon Supplementation on Plasma Lipid Concentrations: A Systematic Review and Meta-Analysis. Journal of Clinical Lipidology. ISSN 1933-2874

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Background: Cinnamon is a rich botanical source of polyphenols, whose positive effects on blood lipid concentrations have been hypothesized, but have not been conclusively studied.
Objective: To systematically review and evaluate the effect of administration of cinnamon on blood lipid concentrations.
Methods: We assessed 13 RCTs with 750 participants investigating the effect of cinnamon supplementation on blood lipid concentrations. A meta-analysis was performed using randomeffect models, with weighted mean differences (with 95% CI) for endpoints calculated using a random-effects model.
Results: No statistically significant effect of cinnamon was observed on blood LDL-C (WMD: - 0.16 mmol/L [-6.19 mg/dL], 95% CI: -0.35, 0.03 [-13.53, 1.16], p = 0.10) and HDL-C (WMD: 0.05 mmol/L [1.92 mg/dL], 95% CI: -0.03, 0.12 [-0.03, 4.64], p = 0.21) concentrations. However, a statistically significant reduction in blood triglycerides (WMD: -0.27 mmol/L [- 23.91 mg/dL], 95% CI: -0.39, -0.14 [-34.54, -12.40], p < 0.01) and total cholesterol concentrations (WMD: -0.36 mmol/L [-13.92 mg/dL], 95% CI: -0.63, -0.09 [-24.36, -3.48], p < 0.01) was observed. HDL-C was significantly elevated following the omission of one study (WMD: 0.04 mmol/L [1.54 mg/dL], 95% CI: 0.03, 0.06 [1.16, 2.32], p < 0.01) during our sensitivity analysis. A meta-regression analysis was conducted and no significant association was found between changes in lipid parameters and cinnamon dose. In contrast, changes in blood levels of total cholesterol (slope: 0.09; 95% CI: 0.02, 0.16; p < 0.01), LDL-C (slope: 0.05; 95% CI: 0.001, 0.10; p = 0.05) and triglycerides (slope: 0.06; 95% CI: 0.04, 0.09; p < 0.01) were significantly and positively associated with the duration of supplementation. No statistically significant association was found between blood HDL-C changes and duration of supplementation.
Conclusion: Cinnamon supplementation significantly reduced blood triglycerides and total cholesterol concentrations without any significant effect on LDL-C and HDL-C.

Item Type: Article
Uncontrolled Keywords: 1101 Medical Biochemistry And Metabolomics, 1102 Cardiovascular Medicine And Haematology
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Elsevier
Date Deposited: 21 Aug 2017 10:10
Last Modified: 04 Sep 2021 11:18
DOI or ID number: 10.1016/j.jacl.2017.08.004
URI: https://researchonline.ljmu.ac.uk/id/eprint/6931
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