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Dawson, EA, Low, DA, Meeuwis, IH, Kerstens, FG, Atkinson, CL, Cable, NT, Green, DJ and Thijssen, DHJ (2015) Reproducibility of cutaneous vascular conductance responses to slow local heating assessed using 7-laser array probes. Microcirculation, 22 (4). pp. 276-284. ISSN 1073-9688
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Abstract
OBJECTIVE: Gradual local heating of the skin induces a largely nitric oxide(NO)-mediated vasodilatation. However, use of this assessment of microvascular health is limited because little is known about its reproducibility. METHODS: Healthy volunteers (n=9) reported twice to the laboratory. Cutaneous vascular conductance (CVC), derived from laser Doppler flux and mean arterial pressure, was examined in response to a standardised local heating protocol (0.5°C per 150s from 33-42°C, followed by 20-minutes at 44°C). Skin responses were examined at two locations on the forearm (between-site). Heating was repeated after a break of 24-72 hours (between-day). Reproducibility of skin-responses at 33-42°C is presented for absolute CVC and relative CVC-responses corrected for maximal CVC at 44°C (%CVCmax ). RESULTS: Between-day reproducibility of baseline CVC and %CVCmax for both sites was relatively poor (22-30%). At 42°C, CVC and %CVCmax responses showed less variation (9-19%), whilst absolute CVC-responses at 44°C were 14-17%. Between-day variation for %CVCmax increased when using data from site 1 on day 1, but site 2 on the subsequent day (25%). CONCLUSION: Day-to-day reproducibility of baseline laser Doppler-derived skin perfusion responses is poor, but acceptable when absolute and relative skin perfusion to a local gradual heating protocol is utilised and site-to-site variation is minimised. This article is protected by copyright. All rights reserved.
| Item Type: | Article |
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| Additional Information: | This is the accepted version of the following article: "Reproducibility of cutaneous vascular conductance responses to slow local heating assessed using 7-laser array probes", which has been published in final form in Microcirculation at http://dx.doi.org/10.1111/micc.12196 |
| Uncontrolled Keywords: | 11 Medical And Health Sciences |
| Subjects: | R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | Wiley |
| Related URLs: | |
| Date Deposited: | 13 Mar 2015 14:50 |
| Last Modified: | 04 Sep 2021 14:34 |
| DOI or ID number: | 10.1111/micc.12196 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/714 |
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