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Towards topical microRNA-directed therapy for epidermal disorders

Ross, K (2017) Towards topical microRNA-directed therapy for epidermal disorders. Journal of Controlled Release. ISSN 0168-3659

Ross_2017_Towards_microRNA-directed_drug_delivery_for_skin_disorders.pdf - Accepted Version
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There remains an unmet dermatological need for innovative topical agents that achieve better long term outcomes with fewer side effects. Modulation of the expression and activity of microRNA (miRNAs) represents an emerging translational framework for the development of such innovative therapies because changes in the expression of one miRNA can have wide-ranging effects on diverse cellular processes associated with disease. In this short review, the roles of miRNA in epidermal development, psoriasis, cutaneous squamous cell carcinoma and re-epithelisation are highlighted. Consideration is given to the delivery of oligonucleotides that mimic or inhibit miRNA function using vehicles such as cell penetrating peptides, spherical nucleic acids, deformable liposomes and liquid crystalline nanodispersions. Formulation of miRNA-directed oligonucleotides with such skin-penetrating epidermal agents will drive the development of RNA-based cutaneous therapeutics for deployment as primary or adjuvant therapies for epidermal disorders.

Item Type: Article
Uncontrolled Keywords: 0903 Biomedical Engineering, 1115 Pharmacology And Pharmaceutical Sciences
Subjects: R Medicine > RL Dermatology
R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Elsevier
Date Deposited: 14 Nov 2017 14:01
Last Modified: 04 Sep 2021 03:37
DOI or ID number: 10.1016/j.jconrel.2017.11.013
URI: https://researchonline.ljmu.ac.uk/id/eprint/7548
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