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Localised cutaneous microvascular adaptation to exercise training in humans

Low, DA, Green, DJ, Cable, NT, Carter, HH, Atkinson, C, Birk, P, Dawson, EA and Thijssen, DHJ (2018) Localised cutaneous microvascular adaptation to exercise training in humans. European Journal of Applied Physiology. ISSN 1439-6319

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Purpose. Exercise training induces adaptation in conduit and resistance arteries in humans, partly as a consequence of repeated elevation in blood flow and shear stress. The stimuli associated with intrinsic cutaneous microvascular adaptation to exercise training have been less comprehensively studied.

Methods. We studied subjects who completed 8-weeks cycle ergometer training, with partial cuff inflation on one forearm to unilaterally attenuate cutaneous blood flow responses during each exercise-training bout. Before and after training, bilateral forearm skin microvascular dilation was determined using cutaneous vascular conductance (CVC: skin flux/blood pressure) responses to gradual localised heater disk stimulation performed at rest (33, 40, 42 and 44°C).

Results. Cycle exercise induced significant increases in forearm cutaneous flux and temperature, which were attenuated in the cuffed arm (2-way ANOVA interaction-effect; P<0.01). We found that forearm CVC at 42°C and 44°C was significantly lower in the uncuffed arm following 8-weeks of cycle training (P<0.01), whereas no changes were apparent in the contralateral cuffed arm (P=0.77, interaction-effect P=0.01).

Conclusions. Lower limb exercise training in healthy young men leads to lower CVC-responses to a local heating stimulus, an adaptation mediated, at least partly, by a mechanism related to episodic increases in skin blood flow and/or skin temperature.

Item Type: Article
Additional Information: This is a post-peer-review, pre-copyedit version of an article published in European Journal of Applied Physiology. The final authenticated version is available online at: https://doi.org/10.1007/s00421-018-3813-3
Uncontrolled Keywords: 1106 Human Movement And Sports Science
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Springer Verlag
Date Deposited: 14 Nov 2017 16:29
Last Modified: 04 Sep 2021 03:36
URI: https://researchonline.ljmu.ac.uk/id/eprint/7554
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