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Trichomonas vaginalis: Clinical relevance, pathogenicity and diagnosis

Edwards, T, Burke, P, Smalley, H and Hobbs, G (2014) Trichomonas vaginalis: Clinical relevance, pathogenicity and diagnosis. Critical Reviews in Microbiology, 42 (3). ISSN 1040-841X

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Trichomonas vaginalis is the etiological agent of trichomoniasis, the most prevalent non-viral sexually transmitted disease worldwide. Trichomoniasis is a widespread, global health concern and occurring at an increasing rate. Infections of the female genital tract can cause a range of symptoms, including vaginitis and cervicitis, while infections in males are generally asymptomatic. The relatively mild symptoms, and lack of evidence for any serious sequelae, have historically led to this disease being under diagnosed, and under researched. However, growing evidence that T. vaginalis infection is associated with other disease states with high morbidity in both men and women has increased the efforts to diagnose and treat patients harboring this parasite. The pathology of trichomoniasis results from damage to the host epithelia, caused by a variety of processes during infection and recent work has highlighted the complex interactions between the parasite and host, commensal microbiome and accompanying symbionts. The commercial release of a number of nucleic acid amplification tests (NAATs) has added to the available diagnostic options. Immunoassay based Point of Care testing is currently available, and a recent initial evaluation of a NAAT Point of Care system has given promising results, which would enable testing and treatment in a single visit.

Item Type: Article
Additional Information: This is an Accepted Manuscript of an article published by Taylor & Francis in Critical Reviews in Microbiology on 10/11/14, available online: http://www.tandfonline.com/10.3109/1040841X.2014.958050
Uncontrolled Keywords: 0605 Microbiology, 1108 Medical Microbiology
Subjects: Q Science > QR Microbiology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Taylor & Francis
Related URLs:
Date Deposited: 15 Nov 2017 11:58
Last Modified: 04 Sep 2021 11:00
DOI or ID number: 10.3109/1040841X.2014.958050
URI: https://researchonline.ljmu.ac.uk/id/eprint/7561
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