Facial reconstruction

Search LJMU Research Online

Browse Repository | Browse E-Theses

The Application of 3D Printing in the Formulation of Multilayered Fast Dissolving Oral Films.

Ehtezazi, T, Algellay, M, Islam, Y, Roberts, M, Dempster, NM and Sarker, SD (2017) The Application of 3D Printing in the Formulation of Multilayered Fast Dissolving Oral Films. Journal of Pharmaceutical Sciences, 107 (4). pp. 1076-1085. ISSN 0022-3549

3D Printing Ref.pdf - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (1MB) | Preview


Fast dissolving oral films (FDFs) provide an alternative approach to increase consumer acceptance by advantage of rapid dissolution and administration without water. Usually FDFs require taste-masking agents. However, inclusion of these excipients could make developing the formulation a challenging task. Hence, this work employed fused-deposition modelling three-dimensional (FDM 3D) printing to produce single-layered (SLFDFs), or multilayered (MLFDFs) films, with taste-masking layers being separated from drug layer. Filaments were prepared containing polyethylene oxide (PEO) with ibuprofen or paracetamol as model drugs at 60°C. Also filaments were produced containing polyvinyl alcohol (PVA) and paracetamol at 130°C. Furthermore, a filament was prepared containing PEO and strawberry powder for taste-masking layer. FDFs were printed at temperatures of 165°C (PEO) or 190ºC (PVA) with plain or mesh designs. HPLC and mass-spectroscopy analysis indicated active ingredient stability during film preparation process. SLFDFs had thicknesses as small as 197±21μm, and MLFDFs had thicknesses starting from 298±15μm. Depending on the formulation and design, mesh SLFDFs presented disintegration time as short as 42±7s, and this was 48±5s for mesh MLFDFs. SLFDFs showed drug content uniformity in the range of 106.0%-112.4%. In conclusion, this study provides proof-of-concept for the manufacturing of FDFs by using 3D printing.

Item Type: Article
Uncontrolled Keywords: 1115 Pharmacology And Pharmaceutical Sciences
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Elsevier
Related URLs:
Date Deposited: 14 Dec 2017 09:54
Last Modified: 04 Sep 2021 10:54
DOI or ID number: 10.1016/j.xphs.2017.11.019
URI: https://researchonline.ljmu.ac.uk/id/eprint/7720
View Item View Item