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Pegoraro, M, Picot, E, Hansen, CN, Kyriacou, CP, Rosato, E and Tauber, E (2015) Gene expression associated with early and late chronotypes in Drosophila melanogaster. Frontiers in Neurology, 6. ISSN 1664-2295
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Gene expression associated with early and late chronotypes in Drosophila melanogaster.pdf - Published Version Available under License Creative Commons Attribution. Download (9MB) | Preview |
Abstract
The circadian clock provides the temporal framework for rhythmic behavioral and metabolic functions. In the modern era of industrialization, work, and social pressures, clock function is jeopardized, and can result in adverse and chronic effects on health. Understanding circadian clock function, particularly individual variation in diurnal phase preference (chronotype), and the molecular mechanisms underlying such chronotypes may lead to interventions that could abrogate clock dysfunction and improve human (and animal) health and welfare. Our preliminary studies suggested that fruit-flies, like humans, can be classified as early rising “larks” or late rising “owls,” providing a convenient model system for these types of studies. We have identified strains of flies showing increased preference for morning emergence (Early or E) from the pupal case, or more pronounced preference for evening emergence (Late or L). We have sampled pupae the day before eclosion (fourth day after pupariation) at 4 h intervals in the E and L strains, and examined differences in gene expression by RNA-seq. We have identified differentially expressed transcripts between the E and L strains, which provide candidate genes for subsequent studies of Drosophila chronotypes and their human orthologs.
| Item Type: | Article |
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| Uncontrolled Keywords: | 1109 Neurosciences, 1103 Clinical Sciences, 1701 Psychology |
| Subjects: | Q Science > QH Natural history > QH301 Biology Q Science > QH Natural history > QH426 Genetics |
| Divisions: | Natural Sciences & Psychology (closed 31 Aug 19) |
| Publisher: | Frontiers Media |
| Date Deposited: | 12 Apr 2018 10:55 |
| Last Modified: | 04 Sep 2021 02:46 |
| DOI or ID number: | 10.3389/fneur.2015.00100 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/8472 |
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