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Relation between age and carotid artery intima-medial thickness: a systematic review.

van den Munckhof, ICL, Jones, H, Hopman, MTE, de Graaf, J, Nyakayiru, J, van Dijk, B, Eijsvogels, TMH and Thijssen, DHJ (2018) Relation between age and carotid artery intima-medial thickness: a systematic review. Clinical Cardiology, 41. pp. 698-704. ISSN 0160-9289

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Carotid artery intima-medial thickness (cIMT) represents a popular measure of atherosclerosis and is predictive of future cardiovascular and cerebrovascular events. Although older age is associated with a higher cIMT, little is known about whether this increase in cIMT follows a linear relationship with age or it is affected under influence of cardiovascular diseases (CVD) or CVD risk factors. We hypothesize that the relationship between cIMT and age is nonlinear and is affected by CVD or risk factors. A systematic review of studies that examined cIMT in the general population and human populations free from CVD/risk factors was undertaken. The literature search was conducted in PubMed, Scopus, and Web of Science. Seventeen studies with 32 unique study populations, involving 10,124 healthy individuals free from CVD risk factors, were included. Furthermore, 58 studies with 115 unique study populations were included, involving 65,774 individuals from the general population (with and without CVD risk factors). A strong positive association was evident between age and cIMT in the healthy population, demonstrating a gradual, linear increase in cIMT that did not differ between age decades (r = 0.91, P < 0.001). Although populations with individuals with CVD demonstrated a higher cIMT compared to populations free of CVD, a linear relation between age and cIMT was also present in this population. Our data suggest that cIMT is strongly and linearly related to age. This linear relationship was not affected by CVD or risk factors.

Item Type: Article
Additional Information: This is the accepted version of the following article: van den Munckhof ICL, Jones H, Hopman MTE, et al. Relation between age and carotid artery intima‐medial thickness: a systematic review. Clin Cardiol. 2018;41:698–704., which has been published in final form at http://dx.doi.org/10.1002/clc.22934
Uncontrolled Keywords: 1102 Cardiovascular Medicine And Haematology
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Wiley
Related URLs:
Date Deposited: 25 May 2018 10:36
Last Modified: 04 Sep 2021 10:28
DOI or ID number: 10.1002/clc.22934
URI: https://researchonline.ljmu.ac.uk/id/eprint/8717
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