Facial reconstruction

Search LJMU Research Online

Browse Repository | Browse E-Theses

Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex

Guadalupe, T, Mathias, SR, Vanerp, TGM, Whelan, CD, Zwiers, MP, Abe, Y, Abramovic, L, Agartz, I, Andreassen, OA, Arias-Vasquez, A, Aribisala, BS, Armstrong, NJ, Arolt, V, Artiges, E, Ayesa-Arriola, R, Baboyan, VG, Banaschewski, T, Barker, G, Bastin, ME, Baune, BT , Blangero, J, Bokde, ALW, Boedhoe, PSW, Bose, A, Brem, S, Brodaty, H, Bromberg, U, Brooks, SJ, Buechel, C, Buitelaar, J, Calhoun, VD, Cannon, DM, Cattrell, A, Cheng, Y, Conrod, PJ, Conzelmann, A, Corvin, A, Crespo-Facorro, B, Crivello, F, Dannlowski, U, De Zubicaray, GI, De Zwarte, SMC, Deary, IJ, Desrivieres, S, Doan, NT, Donohoe, G, Dorum, ES, Ehrlich, S, Espeseth, T, Fernandez, G, Flor, H, Fouche, J-P, Frouin, V, Fukunaga, M, Gallinat, J, Garavan, H, Gill, M, Suarez, AG, Gowland, P, Grabe, HJ, Grotegerd, D, Gruber, O, Hagenaars, S, Hashimoto, R, Hauser, TU, Heinz, A, Hibar, DP, Hoekstra, PJ, Hoogman, M, Howells, FM, Hu, H, Pol, HEH, Huyser, C, Ittermann, B, Jahanshad, N, Jonsson, EG, Jurk, S, Kahn, RS, Kelly, S, Kraemer, B, Kugel, H, Kwon, JS, Lemaitre, H, Lesch, K-P, Lochner, C, Luciano, M, Marquand, AF, Martin, NG, Martinez-Zalacain, I, Martinot, J-L, Mataix-Cols, D, Mather, K, McDonald, C, McMahon, KL, Medland, SE, Menchon, JM, Morris, DW, Mothersill, O, Maniega, SM, Mwangi, B, Nakamae, T, Nakao, T, Narayanaswaamy, JC, Nees, F, Nordvik, JE, Onnink, AMH, Opel, N, Ophoff, R, Martinot, M-LP, Orfanos, DP, Pauli, P, Paus, T, Poustka, L, Reddy, JYC, Renteria, ME, Roiz-Santianez, R, Roos, A, Royle, NA, Sachdev, P, Sanchez-Juan, P, Schmaal, L, Schumann, G, Shumskaya, E, Smolka, MN, Soares, JC, Soriano-Mas, C, Stein, DJ, Strike, LT, Toro, R, Turner, JA, Tzourio-Mazoyer, N, Uhlmann, A, Hernandez, MV, Van den Heuvel, OA, Van der Meer, D, Van Haren, NEM, Veltman, DJ, Venkatasubramanian, G, Vetter, NC, Vuletic, D, Walitza, S, Walter, H, Walton, E, Wang, Z, Wardlaw, J, Wen, W, Westlye, LT, Whelan, R, Wittfeld, K, Wolfers, T, Wright, MJ, Xu, J, Xu, X, Yun, J-Y, Zhao, J, Franke, B, Thompson, PM, Glahn, DC, Mazoyer, B, Fisher, SE and Francks, C (2016) Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex. Brain Imaging and Behavior, 11 (5). pp. 1497-1514. ISSN 1931-7557

[img]
Preview
Text
Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex.pdf - Published Version
Available under License Creative Commons Attribution.

Download (750kB) | Preview

Abstract

The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders.

Item Type: Article
Uncontrolled Keywords: 11 Medical And Health Sciences, 17 Psychology And Cognitive Sciences
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Natural Sciences & Psychology (closed 31 Aug 19)
Publisher: SPRINGER
Related URLs:
Date Deposited: 11 Oct 2018 11:47
Last Modified: 04 Sep 2021 02:27
DOI or ID number: 10.1007/s11682-016-9629-z
URI: https://researchonline.ljmu.ac.uk/id/eprint/9286
View Item View Item