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Exercise-induced Changes in Soluble ST2 Concentrations in Marathon Runners.

Aengevaeren, VL, VAN Kimmenade, RRJ, Hopman, MTE, Royen, NVAN, Snider, JV, Januzzi, JL, George, KP and Eijsvogels, TMH (2018) Exercise-induced Changes in Soluble ST2 Concentrations in Marathon Runners. Medicine and Science in Sports and Exercise. ISSN 1530-0315

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PURPOSE: Previous studies have suggested that extreme endurance exercise may induce cardiac micro-damage that could lead to subsequent myocardial fibrosis. Soluble suppression of tumorigenicity (sST2) is a cardiac biomarker for assessment of myocardial fibrosis, inflammation and strain. We evaluated baseline and exercise-induced sST2 concentrations in a heterogeneous cohort of marathon runners to identify predictors for sST2 concentrations. METHODS: Ninety-two runners supplied demographic data, health status, physical activity levels and marathon experience. Before (baseline) and immediately after (finish) the marathon blood was drawn for analysis of sST2 and cTnI. RESULTS: Eighty-two participants (45±8 yrs, 79% male) finished the race in 227±28 min at 92 [88-94]% of their predicted maximum heart rate (exercise intensity). sST2 concentrations increased in all runners, from 34 [25-46] ng/ml to 70 [53-87] ng/ml (p<.001) and cTnI increased from 9 [5-21] ng/L to 60 [34-102] ng/L (p<.001). sST2 concentrations were higher in the fastest marathon runners. Sex and marathon personal best time were associated with baseline sST2 (R=.27); baseline sST2, weight loss and exercise intensity during marathon were associated with finish sST2 (R=.54); baseline sST2, height, sex and weekly training hours were associated with the exercise-induced increase in sST2 (R=.47). We observed no association between sST2 and cTnI concentrations. CONCLUSION: An exercise-induced increase in sST2 was observed in all marathon runners with sST2 concentrations exceeding cut-off values both at baseline (48%) and finish (94%). Faster runners had higher sST2 concentrations. Our data suggest complex variables determine sST2 concentrations in marathon runners.

Item Type: Article
Additional Information: This is a non-final version of an article published in final form in Medicine & Science in Sports & Exercise: VINCENT L. AENGEVAEREN; ROLAND R. J. VAN KIMMENADE; MARIA T.E. HOPMAN; NIELS VAN ROYEN; JAMES V. SNIDER; JAMES L JANUZZI; KEITH P. GEORGE; THIJS M.H. EIJSVOGELS. Exercise-induced Changes in Soluble ST2 Concentrations in Marathon Runners. Medicine & Science in Sports & Exercise. Publish Ahead of Print():, OCT 2018 DOI: 10.1249/MSS.0000000000001806
Uncontrolled Keywords: 1106 Human Movement And Sports Science
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: American College of Sports Medicine
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Date Deposited: 31 Oct 2018 11:35
Last Modified: 03 Sep 2021 21:07
DOI or ID number: 10.1249/MSS.0000000000001806
URI: https://researchonline.ljmu.ac.uk/id/eprint/9573
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