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Methylome of human skeletal muscle after acute & chronic resistance exercise training, detraining & retraining

Seaborne, RA, Strauss, JA, Cocks, MS, Shepherd, SO, O'Brien, TD, van Someren, KA, Bell, PG, Murgatroyd, C, Morton, JP, Stewart, CE, Mein, CA and Sharples, AP (2018) Methylome of human skeletal muscle after acute & chronic resistance exercise training, detraining & retraining. Scientific Data, 5. ISSN 2052-4463

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DNA methylation is an important epigenetic modification that can regulate gene expression following environmental encounters without changes to the genetic code. Using Infinium MethylationEPIC BeadChip Arrays (850,000 CpG sites) we analysed for the first time, DNA isolated from untrained human skeletal muscle biopsies (vastus lateralis) at baseline (rest) and immediately following an acute (single) bout of resistance exercise. In the same participants, we also analysed the methylome following a period of muscle growth (hypertrophy) evoked via chronic (repeated bouts-3 sessions/wk) resistance exercise (RE) (training) over 7-weeks, followed by complete exercise cessation for 7-weeks returning muscle back to baseline levels (detraining), and finally followed by a subsequent 7-week period of RE-induced hypertrophy (retraining). These valuable methylome data sets described in the present manuscript and deposited in an open-access repository can now be shared and re-used to enable the identification of epigenetically regulated genes/ networks that are modified after acute anabolic stimuli and hypertrophy, and further investigate the phenomenon of epigenetic memory in skeletal muscle.

Item Type: Article
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Nature Publishing Group
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Date Deposited: 01 Nov 2018 11:36
Last Modified: 04 Sep 2021 02:17
DOI or ID number: 10.1038/sdata.2018.213
URI: https://researchonline.ljmu.ac.uk/id/eprint/9588
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