Article

Mitchinson, AJ, Pogson, M, Czanner, G, Conway, D, Wilkinson, RR, Murphy, MF, Siekmann, I and Webb, SD (2024) A stochastic model for topographically influenced cell migration. Journal of Theoretical Biology, 581. ISSN 0022-5193

Thompson, CV, Webb, SD, Leedale, JA, Penson, PE, Paini, A, Ebbrell, DJ and Madden, JC (2023) Using Read-Across to Build Physiologically-Based Kinetic Models: Part 2. Case Studies for atenolol and flumioxazin. Computational Toxicology, 29. p. 100293. ISSN 2468-1113

Thompson, CV, Webb, SD, Leedale, JA, Penson, PE, Paini, A, Ebbrell, D and Madden, JC (2023) Using read-across to build physiologically-based kinetic models: Part 1. Development of a KNIME workflow to assist analogue selection for PBK modelling. Computational Toxicology, 29. p. 100292. ISSN 2468-1113

Pletz, J, Allen, T, Madden, JC, Cronin, MTD and Webb, SD (2021) A Mechanistic Model to Study the Kinetics and Toxicity of Salicylic Acid in the Kidney of Four Virtual Individuals. Computational Toxicology, 19. ISSN 2468-1113

Hyndman, L, McKee, S, Mottram, N, Singh, B, Webb, SD and McGinty, S (2020) Mathematical modelling of fluid flow and solute transport to define operating parameters for in vitro perfusion cell culture systems. Interface Focus, 10 (2). ISSN 2042-8898

Kelly, RA, Fitches, M, Webb, SD, Pop, S and Chidlow, SJ (2019) Modelling the effects of glucagon during glucose tolerance testing. Theoretical Biology and Medical Modelling, 16 (21). ISSN 1742-4682

Kyffin, JA, Cox, CR, Leedale, J, Colley, HE, Murdoch, C, Mistry, P, Webb, SD and Sharma, P (2019) Preparation of Primary Rat Hepatocyte Spheroids Utilizing the Liquid-Overlay Technique. Current Protocols in Toxicology, 81 (1). ISSN 1934-9262

Mason, CL, Leedale, J, Tasoulis, S, Jarman, I and Webb, SD (2019) A systems toxicology paracetamol overdose framework: accounting for high-risk individuals. Computational Toxicology, 12. ISSN 2468-1113

Leedale, J, Colley, HE, Gaskell, H, Williams, DP, Bearon, RN, Chadwick, AE, Murdoch, C and Webb, SD (2019) In silico-guided optimisation of oxygen gradients in hepatic spheroids. Computational Toxicology, 12. ISSN 2468-1113

Sorrell, I, Shipley, RJ, Regan, S, Gardner, I, Storm, MP, Ellis, M, Ward, J, Williams, D, Mistry, P, Salazar, JD, Scott, A and Webb, SD (2019) Mathematical modelling of a liver hollow fibre bioreactor. Journal of Theoretical Biology, 475. pp. 25-33. ISSN 0022-5193

Kelly, RA, Leedale, J, Calleja, D, Enoch, SJ, Harrell, A, Chadwick, A and Webb, SD (2019) Modelling changes in glutathione homeostasis as a function of quinone redox metabolism. Scientific Reports. ISSN 2045-2322

Thaventhiran, T, Wong, W, Alghanem, AF, Alhumeed, N, Aljasir, MA, Ramsey, S, Sethu, S, Yeang, HXA, Chadwick, AE, Cross, M, Webb, SD, Djouhri, L, Ball, C, Stebbings, R and Sathish, JG (2019) CD28 Superagonistic Activation of T Cells Induces a Tumor Cell-Like Metabolic Program. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 38 (2). pp. 60-69. ISSN 2167-9436

Madden, JC, Pawar, G, Cronin, MTD, Webb, SD, Tan, Y-M and Paini, A (2019) In Silico Resources to Assist in the Development and Evaluation of Physiologically-Based Kinetic Models. Computational Toxicology, 11. pp. 33-49. ISSN 2468-1113

Tomlinson, L, Lu, ZQ, Bentley, RA, Colley, HE, Murdoch, C, Webb, SD, Cross, MJ, Copple, IM and Sharma, P (2019) Attenuation of doxorubicin-induced cardiotoxicity in a human in vitro cardiac model by the induction of the NRF-2 pathway. Biomedicine & Pharmacotherapy, 112. ISSN 0753-3322

Tomlinson, L, Hyndman, L, Firman, JW, Bentley, R, Kyffin, JA, Webb, SD, McGinty, S and Sharma, P (2019) In vitro Liver Zonation of Primary Rat Hepatocytes. Frontiers in Bioengineering and Biotechnology, 7 (17). ISSN 2296-4185

Kyffin, JA, Sharma, P, Leedale, J, Colley, HE, Murdoch, C, Harding, AL, Mistry, P and Webb, SD (2018) Characterisation of a functional rat hepatocyte spheroid model. Toxicology In Vitro, 55. pp. 160-172. ISSN 0887-2333

Kelly, RA, Leedale, J, Harrell, A, Beard, DA, Randle, LE, Chadwick, AE and Webb, SD (2018) Modelling the impact of changes in the extracellular environment on the cytosolic free NAD+/NADH ratio during cell culture. PLoS One, 13 (11). ISSN 1932-6203

Pletz, J, Enoch, SJ, Jais, DM, Mellor, CL, Pawar, G, Madden, JC, Webb, SD, Tagliati, C and Cronin, MTD (2018) A Critical Review of Adverse Effects to the Kidney: Mechanisms, Data Sources and In Silico Tools to Assist Prediction. Expert Opinion on Drug Metabolism and Toxicology. ISSN 1744-7607

leedale, J, Sharkey, K, Colley, H, Norton, A, Peeney, D, Mason, C, Sathish, J, Murdoch, C, Sharma, P and Webb, SD (2018) A combined in vitro/in silico approach to identifying off-target receptor toxicity. iScience, 4. pp. 84-96. ISSN 2589-0042

Mason, C, Leedale, J, Tasoulis, S, Jarman, IH, Antione, D and Webb, SD (2018) Systems Toxicology Approach to Identifying Paracetamol Overdose. CPT: Pharmacometrics & Systems Pharmacology. ISSN 2163-8306

Kyffin, JA, Sharma, P, Leedale, J, Colley, HE, Murdoch, C, Mistry, P and Webb, SD (2018) Impact of cell types and culture methods on the functionality of in vitro liver systems - A review of cell systems for hepatotoxicity assessment. Toxicology In Vitro, 48. pp. 262-275. ISSN 0887-2333

Madden, JC, Webb, SD, Enoch, SJ, Colley, H, Murdoch, C, Shipley, R, Sharma, P, Yang, C and Cronin, MTD (2017) In silico prediction of skin metabolism and its implication in toxicity assessment. Computational Toxicology. ISSN 2468-1113

Storm, MP, Sorrell, I, Shipley, R, Regan, S, Luetchford, KA, Sathish, J, Webb, SD and Ellis, MJ (2016) Hollow Fiber Bioreactors for In Vivo-like Mammalian Tissue Culture. Journal of Visualized Experiments, 111 (e53431). pp. 1-12. ISSN 1940-087X

Gaskell, H, Sharma, P, Colley, HE, Murdoch, C, Williams, DP and Webb, SD (2016) Characterization of a functional C3A liver spheroid model. Toxicology Research, 5. pp. 1053-1065. ISSN 2045-452X

Webb, SD, Reddyhoff, D, Ward, J, Williams, D and Regan, S (2015) Timescale analysis of a mathematical model of acetaminophen metabolism andtoxicity. Journal of Theoretical Biology, 386. pp. 132-146. ISSN 1095-8541