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Genomic imprinting mediates sexual experience-dependent olfactory learning in male mice

Swaney, WT and Curley, JP and Champagne, FA and Keverne, EB (2007) Genomic imprinting mediates sexual experience-dependent olfactory learning in male mice. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104 (14). pp. 6084-6089. ISSN 0027-8424

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Abstract

Mammalian imprinted genes are generally thought to have evolved as a result of conflict between parents, however recent knockout studies suggest that coadaptation between mother and offspring may have been a significant factor. Here we present evidence that the same imprinted gene that regulates mammalian maternal care and offspring development also regulates male sexual behavior and olfaction. We have shown that the behavior of male mice carrying a knockout of the imprinted gene Peg3 does not change with sexual experience and that they are consequently unable to improve their copulatory abilities or olfactory interest in female odor cues after mating experience. Forebrain activation, as indexed by female odor-induced c-Fos protein induction, fails to increase with sexual experience, providing a neural basis for the behavioral deficits they display. The behavioral and neural effects of the Peg3 knockout show that this imprinted gene has evolved to regulate multiple and varied aspects of reproduction, from male sexual behavior to female maternal care and the development of offspring. Moreover, sexual experience-driven behavioral changes may represent an adaptive response that enables males to increase their reproductive potential over their lifespan, and the effects we have found suggest that the evolution of genomic imprinting has been influenced by coadaptation between males and females, as well as between females and offspring.

Item Type: Article
Uncontrolled Keywords: MD Multidisciplinary
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH426 Genetics
Divisions: Natural Sciences and Psychology
Publisher: National Academy of Sciences
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Date Deposited: 18 Jun 2015 10:15
Last Modified: 08 Sep 2015 13:58
DOI or Identification number: 10.1073/pnas.0609471104
URI: http://researchonline.ljmu.ac.uk/id/eprint/1369

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