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Interval exercise, but not endurance exercise, prevents endothelial ischemia-reperfusion injury in healthy subjects

Seeger, JPH and Lenting, CJ and Schreuder, THA and Landman, TRJ and Cable, NT and Hopman, MTE and Thijssen, DHJ (2015) Interval exercise, but not endurance exercise, prevents endothelial ischemia-reperfusion injury in healthy subjects. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 308 (4). H351-H357. ISSN 0363-6135

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Abstract

Endothelial ischemia-reperfusion (I/R) injury importantly contributes to the poor prognosis during ischemic (myocardial) events. Preconditioning, i.e., repeated exposure to short periods of ischemia, effectively reduces endothelial I/R injury. In the present study, we examined the hypothesis that exercise has preconditioning effects on endothelial I/R injury. Therefore, we studied whether an acute bout of endurance or interval exercise is able to protect against endothelial I/R injury. In 17 healthy young subjects, we examined changes in brachial artery endothelial function using flow-mediated dilation (FMD) before and after a bout of high-intensity interval exercise, moderate-intensity endurance exercise, or a control intervention. Subsequently, I/R injury was induced by inflation of a blood pressure cuff around the upper arm to 220 mmHg for 20 min and 20 min of reperfusion followed by another FMD measurement. Near-infrared spectrometry was used to examine local tissue oxygenation during exercise. No differences in brachial artery FMD were found at baseline for the three conditions. I/R induced a significant decline in FMD (7.1 ± 2.3 to 4.3 ± 2.3, P < 0.001). When preceded by the interval exercise bout, no change in FMD was present after I/R (7.7 ± 3.1 to 7.2 ± 3.1, P = 0.56), whereas the decrease in FMD after I/R could not be prevented by the endurance exercise bout (7.8 ± 3.1 to 3.8 ± 1.7, P < 0.001). In conclusion, a single bout of lower limb interval exercise, but not moderate-intensity endurance exercise, effectively prevents brachial artery endothelial I/R injury. This indicates the presence of a remote preconditioning effect of exercise, which is selectively present after short-term interval but not continuous exercise in healthy young subjects.

Item Type: Article
Uncontrolled Keywords: 0606 Physiology, 1116 Medical Physiology
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: AMER PHYSIOLOGICAL SOC
Related URLs:
Date Deposited: 22 Jan 2016 11:33
Last Modified: 22 Jan 2016 11:33
DOI or Identification number: 10.1152/ajpheart.00647.2014
URI: http://researchonline.ljmu.ac.uk/id/eprint/2754

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