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Combined aerobic and resistance exercise training decreases peripheral but not central artery wall thickness in subjects with type 2 diabetes

Schreuder, THA, Van den Munckhof, I, Poelkens, F, Hopman, MTE and Thijssen, DHJ (2015) Combined aerobic and resistance exercise training decreases peripheral but not central artery wall thickness in subjects with type 2 diabetes. European Journal of Applied Physiology, 115 (2). pp. 317-326. ISSN 1439-6327

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Abstract

Objective
Little is known about the impact of exercise training on conduit artery wall thickness in type 2 diabetes. We examined the local and systemic impact of exercise training on superficial femoral (SFA), brachial (BA), and carotid artery (CA) wall thickness in type 2 diabetes patients and controls.
Methods
Twenty patients with type 2 diabetes and 10 age- and sex-matched controls performed an 8-week training study involving lower limb-based combined aerobic and resistance exercise training. We examined the SFA to study the local effect of exercise, and also the systemic impact of lower limb-based exercise training on peripheral (i.e. BA) and central (i.e. CA) arteries. Wall thickness (WT), diameter and wall:lumen(W:L)-ratios were examined using automated edge detection of ultrasound images.
Results
Exercise training did not alter SFA or CA diameter in type 2 diabetes or controls (all P > 0.05). BA diameter was increased after training in type 2 diabetes, but not in controls. Exercise training decreased WT and W:L ratio in the SFA and BA, but not in CA in type 2 diabetes. Training did not alter WT or W:L ratio in controls (P > 0.05).
Conclusion
Lower limb-dominant exercise training causes remodelling of peripheral arteries, supplying active and inactive vascular beds, but not central arteries in type 2 diabetes.

Item Type: Article
Additional Information: The final publication is available at Springer via http://dx.doi.org/10.1007/s00421-014-3016-5
Uncontrolled Keywords: 1106 Human Movement And Sports Science
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Springer Verlag
Related URLs:
Date Deposited: 22 Jan 2016 11:55
Last Modified: 21 Sep 2018 21:46
DOI or Identification number: 10.1007/s00421-014-3016-5
URI: http://researchonline.ljmu.ac.uk/id/eprint/2756

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