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Combined aerobic and resistance exercise training decreases peripheral but not central artery wall thickness in subjects with type 2 diabetes

Schreuder, THA and Van den Munckhof, I and Poelkens, F and Hopman, MTE and Thijssen, DHJ (2015) Combined aerobic and resistance exercise training decreases peripheral but not central artery wall thickness in subjects with type 2 diabetes. European Journal of Applied Physiology, 115 (2). pp. 317-326. ISSN 1439-6327

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Abstract

Objective
Little is known about the impact of exercise training on conduit artery wall thickness in type 2 diabetes. We examined the local and systemic impact of exercise training on superficial femoral (SFA), brachial (BA), and carotid artery (CA) wall thickness in type 2 diabetes patients and controls.
Methods
Twenty patients with type 2 diabetes and 10 age- and sex-matched controls performed an 8-week training study involving lower limb-based combined aerobic and resistance exercise training. We examined the SFA to study the local effect of exercise, and also the systemic impact of lower limb-based exercise training on peripheral (i.e. BA) and central (i.e. CA) arteries. Wall thickness (WT), diameter and wall:lumen(W:L)-ratios were examined using automated edge detection of ultrasound images.
Results
Exercise training did not alter SFA or CA diameter in type 2 diabetes or controls (all P > 0.05). BA diameter was increased after training in type 2 diabetes, but not in controls. Exercise training decreased WT and W:L ratio in the SFA and BA, but not in CA in type 2 diabetes. Training did not alter WT or W:L ratio in controls (P > 0.05).
Conclusion
Lower limb-dominant exercise training causes remodelling of peripheral arteries, supplying active and inactive vascular beds, but not central arteries in type 2 diabetes.

Item Type: Article
Additional Information: The final publication is available at Springer via http://dx.doi.org/10.1007/s00421-014-3016-5
Uncontrolled Keywords: 1106 Human Movement And Sports Science
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Springer Verlag
Related URLs:
Date Deposited: 22 Jan 2016 11:55
Last Modified: 22 Jan 2016 11:55
DOI or Identification number: 10.1007/s00421-014-3016-5
URI: http://researchonline.ljmu.ac.uk/id/eprint/2756

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